Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men
Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men
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DOI：
10.1093/ajcn/87.5.1181
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发表时间：
2008-05-01
影响因子：
7.1
通讯作者：
Feinle-Bisset, Christine
中科院分区：
文献类型：
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作者：
Feltrin, Kate L.;Little, Tanya J.;Feinle-Bisset, Christine
背景：脂肪酸对胃肠功能和能量摄入的调节取决于其链长。动物研究表明月桂酸（C12）对能量摄入的抑制作用可能比油酸（C18）更有效。目的：比较等量负荷c12和c18对十二指肠（APD）运动、血浆胆囊收缩素（CCK）和肽YY （PYY）浓度、食欲和能量摄入的影响。设计：13名健康男性（20-46岁）分3次进行双盲随机研究。在十二指肠内输注1)C12、2)C18或3)0.9%生理盐水作为对照（输注速率为4 mL/min， C12和C18的能量负荷为0.4 kcal/min） 60 min时，测量APD压力波、血浆激素和食欲感知；在60到90分钟之间，受试者吃一顿饭。对自助餐时的能量摄入进行了量化。结果：C12和c18均降低了胃窦（P < 0.001）和十二指肠（P < 0.01）压力波，刺激了离体幽门压力波（P < 0.01）和血浆CCK (P < 0.001)，两者之间无显著差异。虽然C12和C18均能增加幽门基础压（P < 0.05），但C12的作用大于C18 （P < 0.01）。相比之下，虽然C12和c18都增加了血浆PYY (P < 0.001)，但c18的作用大于C12。c12对能量摄入有抑制作用（P < 0.05），而c18对能量摄入无抑制作用（P < 0.05）。结论：在给药负荷下，C12抑制了能量摄入，而C18没有，C12是更有效的幽门基础压刺激物。这些差异效应显然不能由CCK或PYY分泌的变化来解释。
Background: The regulation of gastrointestinal function and energy intake by fatty acids depends on their chain length. Animal studies suggest that lauric acid (C12) may have more potent suppressive effects on energy intake than does oleic acid (C18).Objective: We compared the effects of equicaloric loads of C 12 and C 18 on antropyloroduodenal (APD) motility, plasma concentrations of cholecystokinin (CCK) and peptide YY (PYY), appetite, and energy intake.Design: Thirteen healthy men (aged 20-46 y) were studied on 3 occasions in double-blind, randomized fashion. APD pressure waves, plasma hormones, and appetite perceptions were measured during 60-min intraduodenal infusions of 1) C12,2) C18, or 3) 0.9% saline as control (rate: 4 mL/min; energy load for C12 and C18: 0.4 kcal/min); between 60 and 90 min, the subjects consumed a meal. Energy intake at a buffet meal was quantified.Results: C12 and C 18 both reduced antral (P < 0.001) and duodenal (P < 0.01) pressure waves and stimulated isolated pyloric pressure waves (P < 0.01) and plasma CCK (P < 0.001), with no differences between them. Although C12 and C18 both increased basal pyloric pressure (P < 0.05), C 12 had a greater effect than did C 18 (P < 0.01). In contrast, although both C 12 and C 18 increased plasma PYY (P < 0.001), C 18 had a greater effect than C12. C 12, but not C 18, suppressed energy intake (P < 0.05).Conclusions: At the load administered, C12, but not C18, suppressed energy intake, and C 12 was a more potent stimulant of basal pyloric pressure. These discrepant effects are not apparently accounted for by changes in CCK or PYY secretion.