MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma
MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma
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DOI：
10.2463/mrms.mp.2015-0013
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发表时间：
2017-01-01
影响因子：
3
通讯作者：
Gabata, Toshifumi
中科院分区：
文献类型：
--
作者：
Ueda, Fumiaki;Aburano, Hiroyuki;Gabata, Toshifumi
目的：目的：应用磁共振波谱（MRS）技术对幕上脑室室管膜下瘤（SIS）和中枢神经细胞瘤（CNC）进行鉴别诊断。他们进行了检查，使用点分辨光谱。测定胆碱（Cho）、N-乙酰天冬氨酸（NAA）、肌醇（MI）和/或甘氨酸（Gly）与肌酸（Cr）的自动计算比值。还进行了Cr对未抑制水（USW）的评价。进行Mann-Whitney U检验以检验代谢物比率差异的显著性。结果：尽管SIS、对照光谱和CNC之间的Cho/Cr有显著性差异（P < 0.0001），但SIS和对照光谱之间的Cho/Cr无显著性差异（P = 0.11）。SIS与CNC（P = 0.04）或对照谱（P < 0.0001）之间的NAA/Cr观察到统计学显著差异。在SIS和对照光谱（P = 0.03）之间以及CNC和对照光谱（P < 0.0006）之间观察到MI和/或Gly与Cr的统计学显著差异。SIS和CNC之间MI和/或Gly与Cr的差异无统计学意义（P = 0.32）。SIS与对照光谱之间（P < 0.0053）、对照光谱与CNC之间（P < 0.0016）、SIS与CNC之间（P < 0.0083）的Cr与USW之间存在显著的统计学差异。在两个SIS中证实了Lac倒置双重峰。结论：MRS可用于鉴别SIS和CNC。
Purpose: The purpose of this study was to discriminate supratentorial intraventricular subependymoma (SIS) from central neurocytoma (CNC) using magnetic resonance spectroscopy (MRS).Methods: Single-voxel proton MRS using a 1.5T or 3T MR scanner from five SISs, five CNCs, and normal controls were evaluated. They were examined using a point-resolved spectroscopy. Automatically calculated ratios comparing choline (Cho), N-acetylaspartate (NAA), myoinositol (MI), and/or glycine (Gly) to creatine (Cr) were determined. Evaluation of Cr to unsuppressed water (USW) was also performed. Mann-Whitney U test was carried out to test the significance of differences in the metabolite ratios. Detectability of lactate (Lac) and alanine (Ala) was evaluated.Results: Although a statistically significant difference (P < 0.0001) was observed in Cho/Cr among SIS, control spectra, and CNC, no statistical difference was noted between SIS and control spectra (P = 0.11). Statistically significant differences were observed in NAA/Cr between SIS and CNC (P = 0.04) or control spectra (P < 0.0001). A statistically significant difference was observed in MI and/or Gly to Cr between SIS and control spectra (P = 0.03), and CNC and control spectra (P < 0.0006). There were no statistical differences between SIS and CNC for MI and/or Gly to Cr (P = 0.32). Significant statistical differences were found between SIS and control spectra (P < 0.0053), control spectra and CNC (P < 0.0016), and SIS and CNC (P < 0.0083) for Cr to USW. Lac inverted doublets were confirmed in two SISs. Triplets of Lac and Ala were detected in four spectra of CNC.Conclusion: The present study showed that MRS can be useful in discriminating SIS from CNC.