Association of airflow limitation with trauma exposure and post-traumatic stress disorder
Association of airflow limitation with trauma exposure and post-traumatic stress disorder
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DOI：
10.1183/09031936.00028010
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发表时间：
2011-05-01
影响因子：
24.3
通讯作者：
Schaeper, C.
中科院分区：
文献类型：
--
作者：
Spitzer, C.;Koch, B.;Schaeper, C.
创伤暴露和创伤后应激障碍（PTSD）与自我报告的哮喘和慢性阻塞性肺病有关。然而，这些条件尚未涉及肺功能的客观措施。1,772名成年人从一般人群进行了评估，他们的病史和肺功能。此外，他们接受了PTSD访谈，并被分配到三组：无创伤;创伤，但没有PTSD;创伤与PTSD. Adapting社会人口学，临床和生活方式因素，PTSD受试者有显着较高的优势比，大多数哮喘相关症状比PTSD阴性参与者（OR 3.2-8.8）。第一秒用力呼气量（FEV 1）与用力肺活量（FVC）的平均比值在PTSD组中最低，而在无创伤暴露的患者中最高。创伤应激与FEV 1和FEV 1/FVC独立相关。与未患PTSD的受试者相比，患PTSD的受试者发生气流受限的风险显著增加（OR 4.2-7.8），这是首次将创伤应激和PTSD分别与肺功能的客观参数联系起来的研究。我们的研究结果表明，创伤暴露和PTSD与气流限制有关，这可能是由炎症过程介导的。
Trauma exposure and post-traumatic stress disorder (PTSD) are associated with self-reported asthma and chronic obstructive pulmonary disease. However, these conditions have not yet been related to objective measures of lung function.1,772 adults from the general population were assessed regarding their medical histories and spirometric lung function. Additionally, they were administered a PTSD interview, and assigned to three groups: no trauma; trauma, but no PTSD; and trauma with PTSD.Adjusting for sociodemographic, clinical and lifestyle factors, subjects with PTSD had significantly higher odds ratios for most asthma-related symptoms than PTSD-negative participants (OR 3.2-8.8). The mean ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) was lowest in the PTSD group and highest in those without trauma exposure. Traumatic stress was independently associated with FEV1 and FEV1/FVC. Participants with PTSD, compared with those without, had a significantly increased risk for airflow limitation independent of its definition (OR 4.2-7.8).This is the first study relating traumatic stress and PTSD, respectively, to objective parameters of lung function. Our findings suggest an association of trauma exposure and PTSD with airflow limitation, which may be mediated by inflammatory processes.