In the elderly, interleukin-6 plasma levels and the-174G>C polymorphism are associated with the development of cardiovascular disease
In the elderly, interleukin-6 plasma levels and the-174G>C polymorphism are associated with the development of cardiovascular disease
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DOI：
10.1161/01.atv.0000040224.49362.60
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发表时间：
2002-12-01
影响因子：
8.7
通讯作者：
Humphries, SE
中科院分区：
文献类型：
--
作者：
Jenny, NS;Tracy, RP;Humphries, SE
目的 - 白细胞介素（IL）-6介导的炎症在一项病例对照心血管健康研究中与水平以及 -174G>C基因型相关。方法和结果 - 病例包括新发心绞痛、心肌梗死（MI）和卒中（5年随访）、已患MI以及磁共振成像（MRI）可检测到的梗死，这些都涉及心血管疾病（CVD）。我们在该研究中对男性和女性（平均年龄73岁）评估了IL - 6。设立了一个对照组和一个无亚临床CVD的组用于比较。-174C等位基因与较高的C反应蛋白（高11%，P = 0.02）、纤维蛋白原（高3%，P = 0.02）以及IL - 6（高5%；P = 0.16）相关。当对照组与无亚临床CVD组比较时，IL - 6与动脉粥样硬化增加相关。当病例组与对照组比较时，未发现与CVD事件有进一步关联。与无 -174C等位基因相比，其存在与MRI梗死风险相关（比值比1.5）。结论 - IL - 6水平可区分有亚临床CVD者和无亚临床CVD者。尽管 -174C等位基因与新发事件无关，但该基因型与炎症和MRI梗死的关联，结合血浆IL - 6的结果，表明IL - 6可能使个体长期易于发生动脉粥样硬化。（《动脉硬化、血栓形成和血管生物学》2002年；22卷：2066 - 2071页）
Objective-Interleukin (IL)-6-mediated inflammation is levels and the -174G>C genotype in a case-control Cardiovascular Health Study.Methods and Results-Cases included incident angina involved in cardiovascular disease (CVD). We assessed IL-6 study of men and women (average age 73 years) within the I myocardial infarction (MI) and stroke (5-year follow-up) prevalent MI, and MRI-detectable infarcts. A control group and a group free of subclinical CVD were used for comparison. The -174C allele was associated with higher C-reactive protein (11% higher, P = 0.02), fibrinogen 3% higher, P=0.02),and IL-6 (5% higher; P=0.16). IL-6 was associated with increased atherosclerosis when the control Group was compared with the Group free of subclinical CVD. No further association with CVD events was found when case groups were compared with the control group. Compared with its absence, presence of the -174C allele was associated with risk of MRI infarcts (odds ratio 1.5).Conclusions-IL-6 levels differentiated those with subclinical CVD from those without. Although the -174C allele was not associated with incident events, associations of the genotype with inflammation and MRI infarcts, combined with the plasma IL-6 results, suggest that IL-6 may chronically predispose an individual to develop atherosclerosis. (Arterioscler Thromb Vasc Biol. 2002;22:2066-2071.).