Gut Microbiota to Microglia: Microbiome Influences Neurodevelopment in the CNS.
Gut Microbiota to Microglia: Microbiome Influences Neurodevelopment in the CNS.
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肠道菌群至小胶质细胞：微生物组影响中枢神经系统的神经发育。
DOI：
10.3390/children10111767
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发表时间：
2023-10-31
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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作者：
The brain is traditionally viewed as an immunologically privileged site; however, there are known to be multiple resident immune cells that influence the CNS environment and are reactive to extra-CNS signaling. Microglia are an important component of this system, which influences early neurodevelopment in addition to modulating inflammation and regenerative responses to injury and infection. Microglia are influenced by gut microbiome-derived metabolites, both as part of their normal function and potentially in pathological patterns that may induce neurodevelopmental disabilities or behavioral changes. This review aims to summarize the mounting evidence indicating that, not only is the Gut–Brain axis mediated by metabolites and microglia throughout an organism’s lifetime, but it is also influenced prenatally by maternal microbiome and diet, which holds implications for both early neuropathology and neurodevelopment.
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DOI：
10.1016/j.bbih.2021.100281
发表时间：
2021-08
期刊：
Brain, behavior, & immunity - health
影响因子：
--
作者：
Bordeleau M;Fernández de Cossío L;Lacabanne C;Savage JC;Vernoux N;Chakravarty M;Tremblay MÈ
通讯作者：
Tremblay MÈ
影响因子：
9.3
作者：
Bordeleau, Maude;Lacabanne, Chloe;Tremblay, Marie-Eve
通讯作者：
Tremblay, Marie-Eve
影响因子：
3.5
作者：
Ballok, DA;Woulfe, J;Sakic, B
通讯作者：
Sakic, B
DOI：
10.1016/j.bbi.2022.02.024
发表时间：
2022-05
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Dunn GA;Mitchell AJ;Selby M;Fair DA;Gustafsson HC;Sullivan EL
通讯作者：
Sullivan EL
DOI：
10.1017/s2040174418000119
发表时间：
2018-12-01
影响因子：
1.7
作者：
Butel, M. -J.;Waligora-Dupriet, A. -J.;Wydau-Dematteis, S.
通讯作者：
Wydau-Dematteis, S.