Divergent synthesis of complex polyketide-like macrolides from a simple polyol fragment.
Divergent synthesis of complex polyketide-like macrolides from a simple polyol fragment.
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从简单的多元醇片段发散合成复杂的聚酮化合物类大环内酯。
DOI：
10.1021/ol052373g
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发表时间：
2005
期刊：
影响因子：
5.2
通讯作者：
Leighton,JamesL
中科院分区：
文献类型：
--
作者：
Zacuto,MichaelJ;Leighton,JamesL
从相同的简单多元醇前体合成了三种立体化学和结构复杂的非天然聚酮大环内酯。这种多元醇片段可以快速大量获得是这些合成的实用性的关键，并允许靶向更高度复杂和“天然产物样”的大环内酯。
Three stereochemically and structurally complex non-natural polyketide macrolides have been synthesized from the same simple polyol precursor. That this polyol fragment is rapidly available in quantity is key to the practicality of these syntheses and allows the targeting of more highly complex and “natural product-like” macrolides.