Positive association of alcohol consumption with incidence of hypertension in adults aged 40 years and over: Use of repeated alcohol consumption measurements
Positive association of alcohol consumption with incidence of hypertension in adults aged 40 years and over: Use of repeated alcohol consumption measurements
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DOI：
10.1016/j.clnu.2020.01.020
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发表时间：
2020-10-01
影响因子：
6.3
通讯作者：
Lee, Young-Hoon
中科院分区：
文献类型：
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作者：
Jung, Sukyoung;Kim, Mi Kyung;Lee, Young-Hoon
背景与目的：控制饮酒可能是预防高血压的有效途径，高血压是心血管疾病的重要可改变危险因素。然而，很少有证据表明饮酒与高血压发病率之间的时间关系。我们调查了40岁及以上的韩国成年人反复测量酒精摄入量与高血压发病率之间的前瞻性关联。方法：本研究共纳入4989名未服用降压药且血压正常（收缩压< 140 mmHg，舒张压< 90 mmHg）的参与者。我们使用了三种酒精消费测量（基线、最近和平均）作为暴露，并比较了三种方法。使用带有稳健误差估计器的修正泊松回归模型，我们估计了高血压的发病率比（IRRs）和95%置信区间（CIs）。结果：在总共17,689人年（平均3.5年的随访）中，确定了574例高血压事件。在多变量模型中，摄入>= 30 ml/d的酒精与男性高血压风险相关（基线饮酒量的IRR = 1.72, 95% CI = 1.20-2.48， p趋势= 0.017；最近饮酒量的IRR = 1.69, 95% CI = 1.23-2.33， p趋势= 0.005；平均饮酒量的IRR = 1.49, 95% CI = 1.09-2.03， p趋势= 0.014）。在对基线血压进行额外调整后，只有在使用最近的酒精消耗测量时，才存在正相关。女性饮酒与高血压之间无显著相关性，饮酒与基线血压水平对高血压发病率无交互作用（p交互作用均为0.05）。结论：饮酒量，尤其是每天饮用>= 30 ml的人，可能与男性高血压发病风险呈正相关。(C) 2020爱思唯尔有限公司和欧洲临床营养与代谢学会。版权所有。
Background & aims: Managing alcohol consumption may be an effective way of preventing hypertension, which is an important modifiable risk factor for cardiovascular diseases. However, there is little evidence on the temporal relationship between alcohol consumption and incidence of hypertension. We investigated the prospective association between repeated measures of alcohol consumption and hypertension incidence among Korean adults aged 40 and over.Methods: This study included a total of 4989 participants that were not taking antihypertensive drugs and had normal blood pressure (BP) (systolic < 140 mmHg and diastolic < 90 mmHg). We used three measures of alcohol consumption (baseline, most recent, and average) as exposures and compared the three approaches. Using a modified Poisson regression model with a robust error estimator, we estimated incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for hypertension.Results: Over a total of 17,689 person-years (average 3.5 years of follow-up), 574 incident cases of hypertension were identified. In multivariable models, consuming >= 30 ml/d of alcohol was associated with a risk of hypertension among men (IRR = 1.72, 95% CI = 1.20-2.48, p trend = 0.017 for baseline alcohol consumption; IRR = 1.69, 95% CI = 1.23-2.33, p trend = 0.005 for the most recent alcohol consumption; IRR = 1.49, 95% CI = 1.09-2.03, p trend = 0.014 for average alcohol consumption). After additional adjustment for baseline BP the positive association remained only when the most recent alcohol consumption measure was used. There was no significant association between alcohol consumption and hypertension among women, and no interaction effect between alcohol consumption and baseline BP levels on incidence of hypertension (all p interaction > 0.05) existed.Conclusions: Alcohol consumption, especially consuming >= 30 ml/d, may be positively linked with incidence risk of hypertension among men. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.