Iron-catalyzed arylmagnesiation of aryl(alkyl)acetylenes in the presence of an N-heterocyclic carbene ligand.
Iron-catalyzed arylmagnesiation of aryl(alkyl)acetylenes in the presence of an N-heterocyclic carbene ligand.
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DOI：
10.1021/ol063132r
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发表时间：
2007-02
期刊：
影响因子：
5.2
通讯作者：
T. Yamagami;R. Shintani;E. Shirakawa;Tamio Hayashi
中科院分区：
文献类型：
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作者：
T. Yamagami;R. Shintani;E. Shirakawa;Tamio Hayashi
在铁催化剂和 N-杂环卡宾配体存在下，芳基溴化镁与芳基（烷基）乙炔加成，得到高产率的相应烯基镁试剂，通过随后用亲电子试剂处理将其转化为四取代烯烃。 [反应：见正文]
Addition of arylmagnesium bromides to aryl(alkyl)acetylenes proceeded in the presence of an iron catalyst and a N-heterocyclic carbene ligand to give high yields of the corresponding alkenylmagnesium reagents, which were transformed into tetrasubstituted alkenes by subsequent treatment with electrophiles. [reaction: see text]