Cell adhesion molecules, signal transduction and cell growth
Cell adhesion molecules, signal transduction and cell growth
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DOI：
10.1016/s0955-0674(99)00045-9
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发表时间：
1999-12-01
影响因子：
7.5
通讯作者：
Juliano, RL
中科院分区：
文献类型：
--
作者：
Aplin, AE;Howe, AK;Juliano, RL
来自细胞外基质和相邻细胞之间的动态细胞相互作用的信号最终输入到细胞决策过程中。这些相互作用形成了锚定依赖性生长的基础。最近的进展已经提供了整合素和其他细胞粘附分子（CAM）调节由可溶性因子引发的早期信号转导事件和更接近参与细胞周期进程的下游事件的能力背后的机制细节。这些行动似乎取决于计算机辅助管理系统的能力，以启动有组织的结构，允许有效的信息流动的形成。
Signals from dynamic cellular interactions between the extracellular matrix and neighboring cells ultimately input into the cellular decision-making process. These interactions form the basis of anchorage-dependent growth. Recent advances have provided the mechanistic details behind the ability of integrins, and other cell adhesion molecules (CAMs), to regulate both early signal transduction events initiated by soluble factors and downstream events more proximally involved in cell cycle progression. These actions appear to depend on the ability of CAMs to initiate the formation of organized structures that permit the efficient flow of information.