Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water
Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water
复制标题
DOI：
10.1016/j.bbrc.2020.12.035
复制
发表时间：
2021-01-08
影响因子：
3.1
通讯作者：
Cui, Yilong
中科院分区：
文献类型：
--
作者：
Hu, Di;Li, Danxi;Cui, Yilong
活性氧（ROS）是一种高活性物质，直接攻击周围的生物分子，使细胞和组织功能恶化。同时，ROS还作为信号介质通过激活核因子κ B信号通路上调促炎细胞因子的表达，并且增加的促炎细胞因子触发炎症细胞的呼吸爆发，进一步加速炎症组织中ROS的产生。ROS和炎症反应之间的这种串扰导致负面的连锁反应，并导致几种慢性病理的进展。由于已知分子氢优先去除细胞毒性羟基自由基和过氧亚硝酸盐，并防止细胞和组织损伤，因此我们在此研究了富含分子氢和从电极溶解的活性氢储存铂纳米颗粒的电解氢水（EHW）是否可以减轻由连续应激挑战引起的氧化应激和炎症。对大鼠连续5天的应激负荷升高了活性氧代谢衍生化合物（d-ROM）、白细胞介素（IL）-1 β和促肾上腺皮质激素（ACTH）水平，降低了生物抗氧化潜力（BAP）水平。饮用EHW在5天的连续应激负荷显着减轻所有这些变化。结果表明，EHW可以抑制应激反应相关的氧化应激和IL-1 β水平的升高在体内，饮用EHW是有效的控制应激反应，通过其抗氧化潜力。(C)2020年，任作家。爱思唯尔公司出版
Reactive oxygen species (ROS) are highly reactive and directly attack surrounding biomolecules to deteriorate cellular and tissue functions. Meanwhile, ROS also serve as signaling mediators to upregulate pro-inflammatory cytokine expression via activation of the nuclear factor kappa B signaling pathway, and the increased pro-inflammatory cytokines trigger respiratory burst of inflammatory cells that further accelerates ROS production in the inflamed tissue. Such crosstalk between ROS and inflammatory responses leads to a chain reaction of negativity, and cause progression of several chronic pathologies. Since molecular hydrogen is known to preferentially remove cytotoxic hydroxyl radicals and peroxynitrites, and to prevent cell and tissue damage, we here examined whether electrolyzed hydrogen water (EHW) enriched with molecular hydrogen and reactive hydrogen storing platinum nanoparticles dissolved from an electrode could alleviate oxidative stress and inflammation induced by continuous stress challenges. Five-day continuous stress loading to rats elevated reactive oxygen metabolites-derived compounds (d-ROMs), interleukin (IL)-1 beta, and adrenocorticotropic hormone (ACTH) levels and decreased the biological antioxidant potential (BAP) level. Drinking EHW during 5-day continuous stress loading significantly alleviated all of these changes. The results suggest that EHW could suppress stressresponse-associated oxidative stress and IL-1 beta level elevation in vivo, and that drinking of EHW is effective for controlling stress responses via its antioxidant potential. (C) 2020 The Authors. Published by Elsevier Inc.