Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide.
Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide.
复制标题
自杀受害者的蓝斑中与α2-肾上腺素受体结合的激动剂升高。
DOI：
10.1046/j.1471-4159.1994.63020617.x
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发表时间：
1994
影响因子：
4.7
通讯作者：
Halaris,A
中科院分区：
文献类型：
--
作者：
Ordway,GA;Widdowson,PS;Smith,KS;Halaris,A
在10对未服用抗抑郁药的自杀患者和年龄匹配的对照组中，用放射自成像技术测量了激动剂p‐[125I]碘多氯定和拮抗剂[3H]育亨宾与α2‐肾上腺素受体的结合。与对照组相比，自杀受害者蓝斑中受体与α2 -肾上腺素受体的结合明显增加。相比之下，受体拮抗剂与蓝斑α2‐肾上腺素受体的结合在对照组和自杀组之间没有显著差异。对蓝斑组织切片的去甲肾上腺素的高效液相色谱分析没有发现对照组和自杀受害者之间的差异，这表明激动剂结合的差异并不是内源性激动剂去甲肾上腺素在组织切片中保留的差异。自杀受害者蓝斑中受体激动剂与α2 -肾上腺素受体结合的增加，与自抑制α2 -肾上腺素受体高亲和力状态的表达改变与自杀有关。
The binding of an agonist,p‐[125I]iodoclonidine, and an antagonist, [3H]yohimbine, to α2‐adrenoceptors was measured autoradiographically in the locus coeruleus from 10 pairs of antidepressant‐free victims of suicide and age‐matched controls. Agonist binding to α2‐adrenoceptors was significantly greater in the locus coeruleus from victims of suicide compared with control subjects. In contrast, antagonist binding to α2‐adrenoceptors in the locus coeruleus did not differ significantly between control and suicide subjects. HPLC analysis of norepinephrine in tissue sections of the locus coeruleus did not reveal any differences between control subjects and suicide victims, suggesting that differences in agonist binding are not a result of differences in retention of the endogenous agonist norepinephrine in tissue sections. The increase in agonist binding to α2‐adrenoceptors in the locus coeruleus of victims of suicide links an altered expression of the high‐affinity state of autoinhibitory α2‐adrenoceptors with suicide.