Ventral hippocampus spikes during sleep, wakefulness, and arousal in the cat.
Ventral hippocampus spikes during sleep, wakefulness, and arousal in the cat.
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DOI：
10.1093/sleep/1.3.231
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发表时间：
1978-09
期刊：
影响因子：
5.6
通讯作者：
K. Hartse;S. Eisenhart;B. Bergmann;A. Rechtschaffen
中科院分区：
文献类型：
--
作者：
K. Hartse;S. Eisenhart;B. Bergmann;A. Rechtschaffen
研究了腹侧海马体（VH）高振幅（100—300微伏）峰电位（持续时间50—100毫秒）与睡眠-觉醒阶段的关系。对5只长期植入的猫进行48小时连续记录，通过综合脑电图和肌电信号的数字化输出和自动设备的VH峰值定量评分。(1) VH尖峰率与脑电图分期有很强的相关性。在清醒和矛盾睡眠（PS）期间，尖峰很少出现。它们总是在非快速眼动（NREM）睡眠阶段最频繁，通过困倦，中振幅慢波活动和高振幅慢波活动逐渐增加。(2)在清醒状态下，VH峰值率与行为唤醒水平呈负相关。在出现新的实验刺激时，发生率最低，在自发运动时较高，在安静清醒时最高。(3) VH峰值预测了独立于量化EEG的阶段变化。在非快速眼动睡眠开始前的30秒清醒时期以及PS和非快速眼动睡眠之间的过渡时期，峰值率比之前的基线水平有所增加。在非快速眼动睡眠前30秒的基线水平上，它们显著下降。这些结果表明，VH尖峰可能是非快速眼动睡眠的一个有用的非皮层指标。在清醒状态和预期阶段变化时，它可以比脑电图更敏感地指示睡眠过程或觉醒水平。
The relationship between high amplitude (100--300- micro V) spike potentials (50--100 msec duration) in the ventral hippocampus (VH) and sleep-wakefulness stages was investigated. Forty-eight hours of continuous recordings taken from 5 chronically implanted cats were quantitatively scored for stage by digitized outputs of integrated EEG and electromyographic signals and for VH spikes by automatic devices. (1) A very strong relationship was observed between VH spike rates and EEG stage. Spikes were rare during wakefulness and paradoxical sleep (PS). They were always most frequent during nonrapid eye movement (NREM) sleep stages, progressively increasing through drowsiness, moderate amplitude slow wave activity, and high amplitude slow wave activity. (2) VH spike rates varied inversely with level of behavioral arousal within wakefulness. Rates were lowest during the presentation of novel experimental stimuli, higher during spontaneous movement, and highest during quiet wakefulness. (3) VH spikes anticipated stage changes independent of the quantified EEG. Spike rates increased from previous baseline levels in the 30 sec epoch of waking immediately preceding NREM sleep onset and in the transition period between PS and NREM sleep. They decreased significantly from previous base-line levels in the 30 sec epoch of NREM sleep preceding either waking or PS. These results show that the VH spike is a potentially useful noncortical indicator of NREM sleep. Within wakefulness and in the anticipation of stage changes it can be a more sensitive indicator of sleep processes or arousal level than the EEG.