Association between physical activity and mortality in the Japanese general population with mild to moderate impaired renal function: the Jichi Medical School (JMS) cohort study
Association between physical activity and mortality in the Japanese general population with mild to moderate impaired renal function: the Jichi Medical School (JMS) cohort study
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肾功能轻度至中度受损的日本普通人群的体力活动与死亡率之间的关联：自治医学院 (JMS) 队列研究
DOI：
10.1007/s10157-022-02301-1
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发表时间：
2022
影响因子：
2.3
通讯作者：
Ojima Toshiyuki
中科院分区：
文献类型：
--
作者：
Kinoshita-Katahashi Naoko;Shibata Yosuke;Yasuda Hideo;Ishikawa Shizukiyo;Gotoh Tadao;Nakamura Yosizkazu;Kayaba Kazunori;Ojima Toshiyuki
研究背景在肾功能受损的普通人群中，体力活动量或强度与死亡率之间的关系尚不清楚。我们评估了这些关系与肾功能受损的日本居民。MethodsWe分析了638个人估计肌酐清除率低于60毫升/分钟的Jichi医学院队列研究。暴露量包括每日体力活动量（转换为Frachial研究中使用的体力活动指数（派））和每种强度的活动时间。体力活动强度分为久坐和非久坐。非久坐活动进一步分为轻度和中度至剧烈的体力活动（MVPA）。结局为全因死亡。四分位数的曝光，并使用考克斯比例风险model.ResultsThe的平均年龄为63.3岁，72.4%的女性计算风险比（HR）。在11，567人-年期间，共登记了172例死亡。派与死亡率之间无显著相关性。长时间久坐与死亡率增加之间存在显著相关性（p= 0.042）。关于非久坐活动，Q2、Q3和Q4与Q1相比的HR [95%置信区间（CI）]分别为0.85（0.55-1.31）、0.67（0.41-1.08）和0.90（0.54-1.45）。在光强度活动的细分分析中，Q2、Q3和Q4相对于Q1的HR（95% CI）分别为0.53（0.33-0.84）、0.51（0.34-0.82）和0.57（0.34-0.96）。MVPA和mortality.ConclusionsNonsedentary活动，特别是光强度的活动，显着降低肾功能受损的居民之间的死亡率之间没有显着的关联。
BackgroundThe association between physical activity volume or intensity and mortality in general population with impaired renal function is unclear. We assessed these relationships among Japanese residents with impaired renal function.MethodsWe analyzed 638 individuals with estimated creatinine clearance below 60 ml/min in the Jichi Medical School cohort study. Exposures included the daily amount of physical activity converted to the physical activity index (PAI) used in the Framingham study and the activity time for each intensity. Physical activity intensity was classified into sedentary and nonsedentary. Nonsedentary activity was further divided into light-intensity and moderate-to-vigorous physical activity (MVPA). The outcome was all-cause mortality. Quartiles of the exposures were created, and hazard ratios (HRs) were calculated using the Cox proportional hazards model.ResultsThe mean age of the subjects was 63.3 years, and 72.4% were female. In total, 172 deaths were registered during 11,567 person-years. No significant association was found between PAI and mortality. A significant association was found between long sedentary time and increased mortality (p= 0.042). Regarding nonsedentary activity, the HRs [95% confidence intervals (CIs)] for Q2, Q3, and Q4 versus Q1 were 0.85 (0.55–1.31), 0.67 (0.41–1.08), and 0.90 (0.54–1.45), respectively. In the subdivided analysis for light-intensity activity, the HRs (95% CIs) of Q2, Q3, and Q4 versus Q1 were 0.53 (0.33–0.84), 0.51 (0.34–0.82), and 0.57 (0.34–0.96), respectively. No significant association was found between MVPA and mortality.ConclusionsNonsedentary activity, especially light-intensity activity, significantly reduced mortality among residents with impaired renal function.