Dysregulation of redox pathways in liver fibrosis.
Dysregulation of redox pathways in liver fibrosis.
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DOI：
10.1152/ajpgi.00050.2016
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Natalie J Torok
中科院分区：
文献类型：
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作者：
Natalie J Torok
活性氧参与生理信号传导和细胞命运决定。在慢性肝病中，持续和增加的氧化自由基产生驱动纤维化反应，这是疾病进展的常见特征。尽管我们了解肝脏中主要促氧化酶的生物学、其靶点和抗氧化机制，但仍然缺乏关于其在纤维化发病机制中的确切作用的知识。本综述将探讨生理氧化还原信号在肝脏中的作用，提供了一个概述在促氧化剂和抗氧化剂途径，在纤维化过程中失调的最新进展，并强调可能的新的治疗目标。
Reactive oxygen species are implicated in physiological signaling and cell fate decisions. In chronic liver diseases persistent and increased production of oxidative radicals drives a fibrogenic response that is a common feature of disease progression. Despite our understanding the biology of the main prooxidant enzymes, their targets, and antioxidant mechanisms in the liver, there is still lack of knowledge concerning their precise role in the pathogenesis of fibrosis. This review will examine the role of physiological redox signaling in the liver, provide an overview on recent advances in prooxidant and antioxidant pathways that are dysregulated during fibrosis, and highlight possible novel treatment targets.