Long-term retention of early Pavlovian fear conditioning in infant rats.
Long-term retention of early Pavlovian fear conditioning in infant rats.
复制标题
幼鼠早期巴甫洛夫恐惧调节的长期保留。
DOI：
10.1037//0097-7403.2.1.48
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
B. Campbell
中科院分区：
文献类型：
--
作者：
X. Coulter;A. C. Collier;B. Campbell
生物体无法记住婴儿期发生的事件可能是由于发育期间生物体体积增加而加剧的常见遗忘过程，或者是一个独特的过程，例如早期经历时神经发育不足。为了建立婴儿遗忘的独特性，通过将婴儿大鼠暴露于“非基线”巴甫洛夫恐惧条件反射并评估独立建立的压杆后无设备条件刺激的效果，使大小变化无关紧要。在实验1中，酒吧按大鼠暴露于巴甫洛夫应急时，20-22天大的条件刺激后1和42天的条件反射基本上抑制。在实验2中，当17-19和20-22日龄时条件化的幼仔再次表现出优异的保持力，而当11-13和14-16日龄时条件化的幼仔在42天后表现出完全遗忘。在实验3中，14-16天大的幼鼠在5天后记忆良好，10天后记忆较差，20天后完全不记得。这些发现表明，大小的变化可能有助于遗忘发生在发展后期的事件，但神经不成熟可能是遗忘早期事件的基础。
That organisms cannot remember events occurring during infancy may be the result of common forgetting processes exacerbated by the organism's increase in size during development or a unique process such as insufficient neurological development at the time of the early experience. To establish the uniqueness of infantile forgetting, size change was made irrelevant by exposing infant rats to "off-baseline" Pavlovian fear conditioning and assessing the effect of an apparatus-free conditioned stimulus upon independently established bar pressing. In Experiment 1, bar pressing by rats exposed to Pavlovian contingencies when 20-22 days old was substantially suppressed by the conditioned stimulus both 1 and 42 days after conditioning. In Experiment 2, pups conditioned when 17-19 and 20-22 days old again showed excellent retention, whereas pups conditioned when 11-13 and 14-16 days old showed total forgetting 42 days later. In Experiment 3, pups conditioned when 14-16 days old remembered well after 5 days, less well 10 days later, and not at all after 20 days. These findings suggest that size change may contribute to the forgetting of events occurring late in development, but that neurological immaturity may underly the forgetting of earlier events.