High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein
High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein
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DOI：
10.1006/cyto.1999.0533
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发表时间：
2000-03-01
期刊：
影响因子：
3.8
通讯作者：
Toepfer, M
中科院分区：
文献类型：
--
作者：
Hartmann, G;Tschöp, M;Toepfer, M
低氧性肺血管收缩与高原肺水肿（HAPO）的发生有关，但可能不足以导致HAPO的发生。低氧可诱导免疫细胞和内皮细胞的炎症反应，推测高原低氧诱导的炎性细胞因子可能通过引起肺毛细血管渗漏而促进HAPO的发生。我们感兴趣的是，这种炎症反应，可能参与了后来的发展HAPO，是在高海拔地区的个人没有HAPO检测。我们在两项独立的研究中检测了白细胞介素6（IL-6）、白细胞介素1受体拮抗剂（IL-1 ra）和C反应蛋白（CRP）的血浆水平：研究A，瑞士少女峰，在3458 m处过夜，n=12;研究B：Capanna Regina马尔盖丽塔，意大利，在3647 m处过夜3次，在4559 m处过夜1次，n=10。在这两项研究中，先证者均表现出急性高山病症状，但无HAPO体征。在少女峰，IL-6从0.1 +/- 0.03 pg/ml增加到2.0 +/- 0.5 pg/ml（第2天，P=0.03），IL-1 ra从101 +/- 21到284 +/- 73 pg/ml（第2天，P=0.01），CRP从1.0 +/- 0.4到5.8 +/- 1.5 μ g/ml（第4天，P=0.01）。在Capanna马尔盖丽塔，IL-6从0.5 +/- 0.2 pg/ml增加到2.0 +/- 0.8 pg/ml（P=0.02），IL-1 ra从118 +/- 25增加到213 +/- 28 pg/ml（P=0.02），CRP从0.4 +/- 0.03增加到3.5 +/- 1.1 μ g/ml（P=0.03）。IL-8低于ELISA的检测限（
Hypoxic pulmonary vasoconstriction is associated with but may not be sufficient for the development of high-altitude pulmonary oedema (HAPO), Hypoxia is known to induce an inflammatory response in immune cells and endothelial cells, It has been speculated that hypoxia-induced inflammatory cytokines at high altitude may contribute to the development of HAPO by causing capillary leakage in the lung. We were interested if such an inflammatory response, possibly involved in a later development of HAPO, is detectable at high altitude in individuals without HAPO. We examined the plasma levels of interleukin 6 (IL-6), interleukin 1 receptor antagonist (IL-1ra) and C-reactive protein (CRP) in two independent studies: study A, Jungfraujoch, Switzerland, three overnight stays at 3458 m, n=12; study B: Capanna Regina Margherita, Italy, 3 overnight stays at 3647 m and one overnight stay at 4559 m, n=10, In both studies, probands showed symptoms of acute mountain sickness but no signs of HAPO. At the Jungfraujoch, IL-6 increased from 0.1 +/- 0.03 pg/ml to 2.0 +/- 0.5 pg/ml (day 2, P=0.03), IL-1ra from 101 +/- 21 to 284 +/- 73 pg/ml (day 2, P=0.01), and CRP from 1.0 +/- 0.4 to 5.8 +/- 1.5 mu g/ml (day 4, P=0.01). At the Capanna Margherita, IL-6 increased from 0.5 +/- 0.2 pg/ml to 2.0 +/- 0.8 pg/ml (P=0.02), IL-1ra from 118 +/- 25 to 213 +/- 28 pg/ml (P=0.02), and CRP from 0.4 +/- 0.03 to 3.5 +/- 1.1 mu g/ml (P=0.03). IL-8 was below the detection limit of the ELISA (