Biodegradable rare earth fluorochloride nanocrystals for phototheranostics.
Biodegradable rare earth fluorochloride nanocrystals for phototheranostics.
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用于光治疗的可生物降解稀土氟氯化物纳米晶体。
DOI：
10.1039/d0ra00760a
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发表时间：
2020
期刊：
影响因子：
3.9
通讯作者：
Tan,MeiChee
中科院分区：
文献类型：
--
作者：
Zhao,Xinyu;Yu,Qi;Yuan,Jun;Thakor,NitishV;Tan,MeiChee
稀土 (RE) 掺杂无机纳米晶体已被证明是深部组织短波红外 (SWIR) 成像的有效造影剂，具有高灵敏度，可实现肿瘤的早期检测。然而，一个潜在的担忧是无机纳米晶体未知的长期毒性和不相容性。在这项工作中，设计了涂覆有聚多巴胺的 Nd 掺杂 SrFCl 的可生物降解稀土纳米晶体（SrFCl:Nd@PDA）。使用具有低声子能量的氯化SrF2（即SrFCl）代替传统的氟化物主体，其显着提高了SrFCl:Nd在短波红外区域的亮度。涂覆近红外吸收 PDA 层后，SrFCl:Nd 纳米粒子不仅可以用作光声成像的造影剂，而且可以用作癌症治疗的潜在光热剂。此外，这些SrFCl:Nd@PDA纳米粒子可以在磷酸盐缓冲溶液中在1小时内快速完全降解，这有效地解决了潜在的长期积累所产生的有害影响的问题。在肿瘤部位的积累和保留增加，以及注射后约 6 小时体内完全清除，使这些 SrFCl:Nd@PDA 纳米颗粒成为一种有前途的可降解光治疗剂。
Rare earth (RE) doped inorganic nanocrystals have been demonstrated as efficient contrast agents for deep tissue shortwave-infrared (SWIR) imaging with high sensitivities leading to potential early detection of tumors. However, a potential concern is the unknown long-term toxicity and incompatibility of inorganic nanocrystals. In this work, biodegradable rare earth nanocrystals of Nd doped SrFCl coated with polydopamine (SrFCl:Nd@PDA) were designed. Instead of traditional fluoride hosts, the chlorinated SrF2 (i.e. SrFCl) with low phonon energy which significantly improved the brightness of SrFCl:Nd in the SWIR region was used as the host. After coating with a NIR-absorptive PDA layer, the SrFCl:Nd nanoparticles serve as not only a contrast agent for photoacoustic imaging, but also a potential photothermal agent for cancer therapy. Moreover, these SrFCl:Nd@PDA nanoparticles can be rapidly and completely degraded in phosphate buffer solution within 1 h, which effectively addresses the concerns of the deleterious effects arising from potential long term accumulation. The increased accumulation and retention at tumor sites, and complete in vivo clearance ∼6 h after injection make these SrFCl:Nd@PDA nanoparticles a promising degradable phototheranostic agent.