Traditional Chinese medicine Pingchan granule for motor symptoms and functions in Parkinson's disease: A multicenter, randomized, double-blind, placebo-controlled study
Traditional Chinese medicine Pingchan granule for motor symptoms and functions in Parkinson's disease: A multicenter, randomized, double-blind, placebo-controlled study
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中药平禅颗粒治疗帕金森病运动症状和功能：一项多中心、随机、双盲、安慰剂对照研究
DOI：
10.1016/j.phymed.2022.154497
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发表时间：
2022-10-22
期刊：
影响因子：
7.9
通讯作者：
Ye, Qing
中科院分区：
文献类型：
--
作者：
Gu, Si-Chun;Shi, Rong;Ye, Qing
Background: Pingchan granule (PCG) is a traditional Chinese medicine for Parkinson's disease (PD). Hypothesis/Purpose: This was the first study aiming to evaluate the efficacy and safety of PCG for motor symp-toms, gait impairments and quality of life in PD.Study Design and Methods: In this multicenter, randomized, double-blind, placebo-controlled trial, 292 partici-pants were included and followed for 9 months, randomly assigned at a 1:1 ratio to receive PCG or placebo. The primary outcome was the severity of motor symptoms assessed by Movement Disorder Society Unified Parkin-son's Rating Scale III (MDS-UPDRS-III) motor score. Secondary outcomes included timed up and go test (TUG), functional gait assessment (FGA), freezing of gait (FOG), and quality of life assessed by Parkinson's disease questionnaire (PDQ-39). Assessments were done at baseline (T0), 3 months (T1), 6 months (T2) and 9 months (T3). Trial registration: Chinese Clinical Trial Register, ChiCTR-INR-1,701,194.Results: Generalized estimating equation analyses revealed that PCG group had significantly better improvement in MDS-UPDRS-III motor score than placebo group, as well as its domain scores of axial symptoms, bradykinesia, rigidity, and tremor. Improvements of TUG time, FGA, FOG questionnaire (FOGQ), and PDQ39 scores were also observed.Conclusion: PCG had a long-lasting efficacy for motor symptoms and function in PD with good tolerance, sup-porting that PCG might be a viable alternative in the management of PD.
