COMPLETE SEQUENCING OF THE P53 GENE PROVIDES PROGNOSTIC INFORMATION IN BREAST-CANCER PATIENTS, PARTICULARLY IN RELATION TO ADJUVANT SYSTEMIC THERAPY AND RADIOTHERAPY
COMPLETE SEQUENCING OF THE P53 GENE PROVIDES PROGNOSTIC INFORMATION IN BREAST-CANCER PATIENTS, PARTICULARLY IN RELATION TO ADJUVANT SYSTEMIC THERAPY AND RADIOTHERAPY
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DOI：
10.1038/nm1095-1029
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发表时间：
1995-10-01
期刊：
影响因子：
82.9
通讯作者：
HOLMBERG, L
中科院分区：
文献类型：
--
作者：
BERGH, J;NORBERG, T;HOLMBERG, L
对316例乳腺癌进行了p53基因全编码区序列测定，其中97例为淋巴结阳性，206例为淋巴结阴性。p53表达状态与预后及辅助治疗效果有关。在整个编码序列中，总共有69个单独的突变，其中29个在淋巴结阳性肿瘤中。淋巴结阳性和淋巴结阴性患者的突变位点部分不同。在进化保守区II和V中的p53突变与显著更差的预后相关。辅助全身治疗，特别是他莫昔芬，沿着放疗似乎对p53突变和淋巴结阳性肿瘤的价值较小。
The complete coding region of the p53 gene was sequenced from 316 consecutively presented breast cancers, of which 97 were lymph node positive and 206 were node negative. The p53 status was related to prognosis and effect of adjuvant therapy. In all, 69 individual mutations, 29 in node-positive tumours, were demonstrated throughout the whole coding sequence. The mutation sites were partly different for node-positive and node-negative patients. p53 mutations in the evolutionary conserved regions II and V were associated with significantly worse prognosis. Adjuvant systemic therapy, especially with tamoxifen, along with radiotherapy seemed to be of less value to p53 mutation- and lymph node-positive tumours.