The value of plants used in traditional medicine for drug discovery
The value of plants used in traditional medicine for drug discovery
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DOI：
10.2307/3434847
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发表时间：
2001-03-01
影响因子：
10.4
通讯作者：
Farnsworth, NR
中科院分区：
文献类型：
--
作者：
Fabricant, DS;Farnsworth, NR
在这篇综述中，我们描述并讨论了选择高等植物作为药物开发候选植物的几种方法，这些方法最有可能成功。我们强调来自传统医学（民族医学）的各种系统的信息的作用及其对药物发现目的的效用。我们已经确定了122个化合物的定义结构，从只有94种植物中获得，在全球范围内用作药物，并证明80%的这些具有民族医学用途相同或相关的植物活性成分的当前使用。我们确定并讨论了使用植物作为药物开发起点的优点和缺点，特别是那些用于传统医学的植物。
In this review we describe and discuss several approaches to selecting higher plants as candidates for drug development with the greatest possibility of success. We emphasize the role of information derived from various systems of traditional medicine (ethnomedicine) and its utility for drug discovery purposes. We have identified 122 compounds of defined structure, obtained from only 94 species of plants, that are used globally as drugs and demonstrate that 80% of these have had an ethnomedical use identical or related to the current use of the active elements of the plant. We identify and discuss advantages and disadvantages of using plants as starting points for drug development, specifically those used in traditional medicine.