BDNF is a novel marker of cognitive function in ageing women: The DR's EXTRA Study
BDNF is a novel marker of cognitive function in ageing women: The DR's EXTRA Study
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DOI：
10.1016/j.nlm.2008.07.014
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发表时间：
2008-11-01
影响因子：
2.7
通讯作者：
Rauramaa, Rainer
中科院分区：
文献类型：
--
作者：
Komulainen, Pirjo;Pedersen, Maria;Rauramaa, Rainer
脑源性神经营养因子（BDNF）是调节脑可塑性的关键分子之一。虽然低循环水平的BDNF已被认为易患阿尔茨海默病，但关于其与一般人群认知功能相关的数据很少。我们评估了血浆BDNF水平和认知之间的关系，在一个有代表性的人口样本的老年男性和女性。受试者（n = 1389）的参与者的剂量反应运动训练（DR的额外）研究和代表一个随机样本的东芬兰人（684名男性和705名女性），57-79岁的基线研究。采用酶联免疫吸附试验（ELISA）测定血浆BDNF水平。认知功能的评估采用了建立阿尔茨海默病登记协会（CERAD）神经心理学成套测试。女性血浆BDNF水平的平均值（+/- SEM）高于男性（1721 +/- 55 vs. 1495 +/- 54 pg/ml，P < 0.001）。在女性中，BDNF减少1 SD会使BAD测试中低分数的风险增加53%（95%CI 1.21-1.92，P < 0.001），简易精神状态检查法中63%（95% CI 1.21-2.20，P = 0.001），单词列表记忆提高56%（95%CI 1.08-2.26，P = 0.019），在单词列表回忆中提高了50%（95%CI 1.10-2.05，P = 0.010），单词列表保存49%（95%CI 1.12-1.99，P = 0.007），单词列表识别64%（95%CI 1.19-2.25，P = 0.002）。对年龄、教育、抑郁、糖代谢受损、心血管疾病、抗高血压药物、降脂药物、性激素使用、吸烟、饮酒、血浆在冰箱中的储存时间和血小板计数进行了校正。BDNF与男性的认知能力无关。目前的数据表明，血浆BDNF是老年妇女记忆和一般认知功能受损的生物标志物。(C)2008年爱思唯尔公司All rights reserved.
Brain-derived neurotrophic factor (BDNF) is one of the key molecules modulating brain plasticity. While low circulating levels of BDNF have been suggested to predispose to Alzheimer's disease, very little data are available on its association with cognitive function in general population. We evaluated the association between plasma BDNF levels and cognition in a representative population sample of ageing men and women.The subjects (n = 1389) were participants of the Dose-Responses to Exercise Training (DR's EXTRA) Study and represent a random sample of Eastern Finnish people (684 men and 705 women), 57-79 years of age at baseline of the study. Plasma BDNF levels were measured by enzyme-linked immunosorbent assay (ELISA). Cognitive function was evaluated using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological test battery.Women had a higher mean (+/- SEM) plasma BDNF level than men (1721 +/- 55 vs. 1495 +/- 54 pg/ml, P < 0.001). In women, 1 SD decrease in BDNF increased the risk for a low score in Naming Test by 53% (95% Cl 1.21-1.92, P < 0.001), in Mini-Mental State Examination by 63% (95% CI 1.21-2.20, P = 0.001), in Word List Memory by 56% (95% Cl 1.08-2.26, P = 0.019), in Word List Recall by 50% (95% Cl 1.10-2.05, P = 0.010), in Word List Saving by 49% (95% Cl 1.12-1.99, P = 0.007), and in Word List Recognition by 64% (95% Cl 1.19-2.25, P = 0.002). Data were adjusted for age, education, depression, impaired glucose metabolism, cardiovascular disease, anti hypertensive medication, lipid lowering medication, use of sex hormones, smoking, alcohol consumption, storing time of plasma in the freezer and platelet count. BDNF was not associated with cognition in men. Present data suggest that plasma BDNF is a biomarker of impaired memory and general cognitive function in ageing women. (C) 2008 Elsevier Inc. All rights reserved.