Effects of home-based bench step exercise on inflammatory cytokines and lipid profiles in elderly Japanese females: A randomized controlled trial
Effects of home-based bench step exercise on inflammatory cytokines and lipid profiles in elderly Japanese females: A randomized controlled trial
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DOI：
10.1016/j.archger.2015.06.017
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发表时间：
2015-11-01
影响因子：
4
通讯作者：
Ohta, Masanori
中科院分区：
文献类型：
--
作者：
Nishida, Yuichiro;Tanaka, Keitaro;Ohta, Masanori
目的：本研究的目的是探讨一个12周的家庭为基础的板凳步锻炼计划对炎症细胞因子和血脂的影响在老年females.Methods：62绝经后女性（65-85岁）被随机分为板凳步锻炼组（n = 31）或对照组（n = 31）。仰卧步锻炼组的受试者被指示以对应于乳酸阈值（LT）的锻炼强度进行仰卧步锻炼，每天三次，每次10-20 min，目标为在家中进行>= 140 min/周，持续12周。在基线和12周时，测定血清脂联素（高分子量脂联素、白细胞介素-4 [IL-4]、IL-5、IL-6、IL-8、IL-15、肿瘤坏死因子-α [TNF-α]、TNF-β和干扰素-γ [IFN-γ]）和血脂（包括高密度脂蛋白胆固醇（HDL-C））。在基线HDL-C水平较低（< 63 mg/dL）的受试者中，LT时的台阶训练显著增加HDL-C水平并降低IFN-γ浓度（p < 0.05）。在运动组中，IFN-γ的变化与HDL-C的变化呈负相关（rho =-0.56，p < 0.01），而在对照组中没有观察到这种相关性。此外，我们所谓的“炎症状态因子”的主成分分析衍生的指数与HDL-C在运动group.Conclusion的变化呈负相关：板凳步骤运动引起的IFN-γ水平的降低可能部分解释了HDL-C水平的改善程度与运动程序。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Purpose: The purpose of the current study was to investigate the effects of a 12-week home-based bench step exercise program on inflammatory cytokines and lipid profiles in elderly females.Methods: Sixty-two postmenopausal females (65-85 years of age) were randomized to either the bench step exercise group (n = 31) or the control group (n = 31). The subjects in the bench step exercise group were instructed to perform bench step exercises at the exercise intensity corresponding to lactate threshold (LT), three times per day 10-20 min each session, for a goal of >= 140 min/week at home for 12 weeks. At baseline and 12 weeks, circulating levels of nine inflammatory cytokines (high-molecular-weight adiponectin, interleukin-4 [IL-4], IL-5, IL-6, IL-8, IL-15, tumor necrosis factor-alpha [TNF-alpha], TNF-beta and interferon-gamma [IFN-gamma]) and serum lipids including high-density lipoprotein cholesterol (HDL-C) were measured.Results: The bench step training at the LT significantly increased HDL-C levels and decreased IFN-gamma concentrations in the subjects with lower (< 63 mg/dL) baseline HDL-C levels (p < 0.05). The change in IFN-gamma inversely correlated with the change in HDL-C in the exercise group (rho = -0.56, p < 0.01), whereas this association was not observed in the control group. Additionally, principal component analysis-derived index of what we called "inflammatory status factor" was inversely associated with the changes in HDL-C in the exercise group.Conclusion: The bench step exercise-induced reduction in the IFN-gamma levels may partially explain the degree of improvement in the HDL-C levels with the exercise program. (C) 2015 Elsevier Ireland Ltd. All rights reserved.