Glutathione s-transferases in pediatric cancer.
Glutathione s-transferases in pediatric cancer.
复制标题
DOI：
10.3389/fonc.2011.00039
复制
发表时间：
2011
影响因子：
4.7
通讯作者：
Lessnick SL
中科院分区：
文献类型：
--
作者：
Luo W;Kinsey M;Schiffman JD;Lessnick SL
谷胱甘肽S-转移酶（GST）是一个广泛表达的多态性酶家族，对内源性和外源性化合物的解毒非常重要。除了通过化合物与谷胱甘肽结合而具有解毒的经典活性外，现在发现许多其他功能与GST有关。GST多态性/功能与人类疾病易感性或治疗结果（主要在成人中）之间的关联已被广泛研究和审查。这个小审查的重点是研究相关的GST流行病学和功能相关的儿科癌症。利用GST在儿科癌症治疗的机会也进行了讨论。
The glutathione S-transferases (GSTs) are a family of ubiquitously expressed polymorphic enzymes important for detoxifying endogenous and exogenous compounds. In addition to their classic activity of detoxification by conjugation of compounds with glutathione, many other functions are now found to be associated with GSTs. The associations between GST polymorphisms/functions and human disease susceptibility or treatment outcome, mostly in adults, have been extensively studied and reviewed. This mini review focuses on studies related to GST epidemiology and functions related to pediatric cancer. Opportunities to exploit GST in pediatric cancer therapy are also discussed.