Tobacco smoking, family history, and the risk of nasopharyngeal carcinoma: a case-referent study in Hong Kong Chinese
Tobacco smoking, family history, and the risk of nasopharyngeal carcinoma: a case-referent study in Hong Kong Chinese
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DOI：
10.1007/s10552-015-0572-x
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发表时间：
2015-06-01
影响因子：
2.3
通讯作者：
Lau, June Sze Man
中科院分区：
文献类型：
--
作者：
Xie, Shao-Hua;Yu, Ignatius Tak-sun;Lau, June Sze Man
本研究旨在探讨吸烟和鼻咽癌家族史与香港华人鼻咽癌发病风险的关系。在2010年6月至2012年12月期间，我们在香港进行了一项个案参照研究，涉及352个事件案例和410名转介者。我们通过面对面访谈收集了NPC的吸烟和家族史信息。病例中有174例（49.4%），参考病例中有131例（32.0%）。与吸烟相关的鼻咽癌的校正优势比（OR）为1.67[95%可信区间（CI） 1.06, 2.61]。观察到吸烟年数和总包年与鼻咽癌风险之间的暴露-反应关系（分别为p = 0.001和p = 0.018）。一级亲属有鼻咽癌病史与鼻咽癌风险增加相关（调整后OR = 4.52, 95% CI 2.39, 8.55）。与兄弟姐妹病史相关的鼻咽癌风险增加（调整后OR = 6.80, 95% CI 2.63, 17.56）高于与父母病史相关的风险增加（调整后OR = 3.04, 95% CI 1.27, 7.25）。有家族史的吸烟者以无家族史的不吸烟者作为参考的调整OR为4.54 （95% CI 1.67, 12.34）。本研究证实吸烟和家族史在香港华人鼻咽癌发病中的重要作用。所提供的证据支持环境暴露和遗传易感性都有助于鼻咽癌风险的认识。
This study aimed to investigate the associations of tobacco smoking and family history of nasopharyngeal carcinoma (NPC) with the risk of NPC in Hong Kong Chinese.Between June 2010 and December 2012, we conducted a case-referent study with 352 incident cases and 410 referents in Hong Kong. We collected information on tobacco smoking and family history of NPC via face-to-face interviews.There were 174 (49.4 %) and 131 (32.0 %) ever-smokers among cases and referents, respectively. The adjusted odds ratio (OR) for NPC related to current smoking was 1.67 [95 % confidence interval (CI) 1.06, 2.61]. Exposure-response relationships were observed between years and total pack-years of smoking, and NPC risk (p = 0.001 and p = 0.018, respectively). History of NPC in first-degree relatives was associated with an increased NPC risk (adjusted OR = 4.52, 95 % CI 2.39, 8.55). The increased NPC risk associated with sibling history (adjusted OR = 6.80, 95 % CI 2.63, 17.56) was higher than that for parental history (adjusted OR = 3.04, 95 % CI 1.27, 7.25). The adjusted OR for ever-smokers with family history using never-smokers without family history as the reference was 4.54 (95 % CI 1.67, 12.34).This study verified the important roles of tobacco smoking and family history on NPC risk among Hong Kong Chinese. The provided evidence supported the knowledge that both environmental exposures and inherited susceptibility contributed to the risk of NPC.