A solid-state NMR comparison of the mineral structure in bone from diseased joints in the horse
A solid-state NMR comparison of the mineral structure in bone from diseased joints in the horse
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DOI：
10.1007/s10853-007-1916-z
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发表时间：
2007-11-01
影响因子：
4.5
通讯作者：
Jaeger, Christian
中科院分区：
文献类型：
--
作者：
Maltsev, Sergey;Duer, Melinda J.;Jaeger, Christian
在这项工作中，从五匹马的关节中研究了软骨下皮质骨材料，根据临床和放射学评估以及组织学结果判断，其中三匹马没有骨关节炎的临床症状或放射学迹象，其中两匹患有骨关节炎关节病。马是人类骨关节炎的良好模型，因此本研究的目的是利用核磁共振 (NMR) 详细研究受骨关节炎影响的骨材料中的骨结构。我们特别报告了通过固态核磁共振对这些样品的矿物结构进行的评估。
In this work, subchondral cortical bone material is investigated from the joints of five horses, three of which presented with no clinical signs or radiographic signs of osteoarthritis and two of which suffered osteoarthritis joint disease, as judged by clinical and radiographic assessment and histological findings. The horse is a good model for osteoarthritis in humans, so the aim of this study is to use nuclear magnetic resonance (NMR) for a detailed investigation of the bone structure in bone material affected by osteoarthritis. In particular, we report on the assessment of the mineral structure of these samples as viewed by solid-state NMR.