Bacterial toxins and the immune system: show me the in vivo targets.
Bacterial toxins and the immune system: show me the in vivo targets.
复制标题
细菌毒素和免疫系统：向我展示体内靶标。
DOI：
10.1084/jem.20050080
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发表时间：
2005-02-07
影响因子：
15.3
通讯作者：
Galan, Jorge E
中科院分区：
文献类型：
--
作者：
Galan, Jorge E
导致持续感染的微生物通常表现出特定的适应能力，使它们能够避免适应性免疫反应。最近，几种细菌毒素在体外被证明可以扰乱免疫细胞功能。然而，这些活动在感染过程中是否相关，以及这些毒素是否特定地进化为扰乱适应性免疫系统，仍有待确定。
Microorganisms that cause persistent infection often exhibit specific adaptations that allow them to avoid the adaptive immune response. Recently, several bacterial toxins have been shown in vitro to disrupt immune cell functions. However, it remains to be established whether these activities are relevant during infection and whether these toxins have specifically evolved to disrupt the adaptive immune system.