Tongue cancer: Is there a difference in survival compared with other subsites in the oral cavity?
Tongue cancer: Is there a difference in survival compared with other subsites in the oral cavity?
复制标题
DOI：
10.1016/j.joms.2005.11.094
复制
发表时间：
2007-02-01
影响因子：
1.9
通讯作者：
Potter, Bryce E.
中科院分区：
文献类型：
--
作者：
Bell, R. Bryan;Kademani, Deepak;Potter, Bryce E.
目的：口腔鳞状细胞癌 (OSCC) 患者治疗的进展混淆了部位在预测总体预后中的重要性。这项回顾性研究的目的是回顾 OSCC 患者的结果，并确定部位是否是生存或无病生存的重要预测因素。 患者和方法：确定了 1993 年至 2003 年在同一机构接受治疗的 233 名可切除 OSCC 手术患者的记录。手术切缘阳性、组织学分级高、侵袭性生物学行为或晚期疾病的患者接受辅助放疗或放化疗。收集人口统计、部位、阶段、病理、治疗和生存数据并进行统计分析，试图确定局部区域控制和无病生存的预测因素。计算每个变量的描述性统计数据，并使用 Kaplan-Meier 方法计算生存率。为了进行比较，患者被分为 2 组：有舌头病变的组 (n = 73) 和所有其他部位的组 (n = 152)。 Cox比例风险模型用于区分各组之间不同的生存率。结果：215名患者，其中104名男性（48％）和111名女性（52％）符合纳入研究的标准。总生存率和无病生存率分别为 56% 和 58%。分期和级别被确定为对生存具有统计学上的显着影响（P = 0.0014，似然比 chi(2) = 0.04，1 个自由度；P = 0.026，chi(2) = 5，1 个自由度）。舌癌患者和口腔其他部位患者的生存率没有显着差异（P = 0.8，chi(2) = 0.04，自由度为 1）。结论：分级和分期是 OSCC 患者总体生存率和无病生存率的重要预测因素。然而，在这项研究中，舌癌患者和口腔其他部位的癌症患者的生存率没有差异。 (C) 2007 年美国口腔颌面外科医师协会。
Purpose: Advances in the management of patients with oral squamous cell carcinoma (OSCC) have confounded the importance of site in predicting overall prognosis. The purpose of this retrospective study was to review the outcome of patients with OSCC and to determine if site is a significant predictor of survival or disease-free survival.Patients and Methods: The records of 233 patients that underwent surgery for resectable OSCC treated at a single institution from 1993 to 2003 were identified. Patients with positive surgical margins, high grade histology, aggressive biologic behavior, or advanced stage disease underwent adjuvant radiotherapy or chemoradiotherapy. The demographics, site, stage, pathologic, treatment, and survival data were collected and statistically analyzed in an attempt to identify predictors of loco-regional control and disease-free survival. Descriptive statistics were calculated for each variable and survival was calculated using the Kaplan-Meier method. For purposes of comparison, patients were divided into 2 groups: those with tongue lesions (n = 73) and all other sites (n = 152). The Cox proportional hazards model was used to distinguish different survival rates between the groups.Results: Two hundred fifteen patients consisting of 104 males (48%) and 111 females (52%) met the criteria for inclusion in the study. Overall and disease-free survival rates were 56% and 58%, respectively. Stage and grade were identified as having a statistically significant effect on survival (P =.0014, likelihood ratio chi(2) = 0.04, 1 degree of freedom; and P =.026, chi(2) = 5, 1 degree of freedom, respectively). There was no significant difference in survival between patients with tongue cancer and other sites in the oral cavity (P =.8, chi(2) =.04, 1 degree of freedom).Conclusions: Grade and stage are significant predictors of overall and disease-free survival for patients with OSCC. In this study, however, there was no survival difference between patients with tongue cancer and cancers located at other sites in the oral cavity. (C) 2007 American Association of Oral and Maxillofacial Surgeons.