Long-term Recordings of Local Field Potentials From Implanted Deep Brain Stimulation Electrodes
Long-term Recordings of Local Field Potentials From Implanted Deep Brain Stimulation Electrodes
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DOI：
10.1227/neu.0b013e3182676b91
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发表时间：
2012-10-01
期刊：
影响因子：
4.8
通讯作者：
Ince, Nuri Firat
中科院分区：
文献类型：
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作者：
Abosch, Aviva;Lanctin, David;Ince, Nuri Firat
背景：丘脑底核脑深部电刺激（DBS）是治疗帕金森病的有效方法。然而，DBS对个体的疾病状态没有响应，并且一旦建立，编程参数就不会改变以反映疾病状态。从DBS电极记录的局部场电位（LFP）正在研究作为帕金森病状态的潜在生物标志物。然而，没有患者数据存在关于LFP发生了什么事，在整个implant.Objective寿命：我们调查是否LFP振幅和肢体运动的反应，急性植入丘脑底核DBS电极的患者和植入2至7年前的患者之间的差异。我们记录了DBS手术时（9例受试者）、初次置入后3周（9例受试者）和植入程控发生器置换术后2 - 7年（中位数：3.5）（11侧）的LFP。在5分钟的休息和30秒的运动时间段内计算相邻触点的3个双极电极导数的LFP功率频谱。单极阻抗数据被用来评估随着时间推移的趋势。结果：初始电极植入（OR）和术后3周时间（P = 0.94）之间的β带LFP振幅没有显著差异。然而，植入程控发生器更换时的β波段振幅低于OR（P = .008）和OR后记录（P = .039）。阻抗测量值随时间下降（P < .001）。结论：DBS植入数年后可记录术后LFP活动，并显示与急性记录期间类似的运动响应曲线，尽管振幅可能降低。这些结果支持基于LFP活动构建闭环、患者响应DBS设备的可行性。
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus is an effective treatment for Parkinson disease. However, DBS is not responsive to an individual's disease state, and programming parameters, once established, do not change to reflect disease state. Local field potentials (LFPs) recorded from DBS electrodes are being investigated as potential biomarkers for the Parkinson disease state. However, no patient data exist about what happens to LFPs over the lifetime of the implant.OBJECTIVE: We investigated whether LFP amplitude and response to limb movement differed between patients implanted acutely with subthalamic nucleus DBS electrodes and patients implanted 2 to 7 years previously.METHODS: We recorded LFPs at DBS surgery time (9 subjects), 3 weeks after initial placement (9 subjects), and 2 to 7 years (median: 3.5) later during implanted programmable generator replacement (11 sides). LFP power-frequency spectra for each of 3 bipolar electrode derivations of adjacent contacts were calculated over 5-minute resting and 30-second movement epochs. Monopolar impedance data were used to evaluate trends over time.RESULTS: There was no significant difference in beta-band LFP amplitude between initial electrode implantation (OR) and 3-week post-OR times (P = .94). However, beta-band amplitude was lower at implanted programmable generator replacement times than in OR (P = .008) and post-OR recordings (P = .039). Impedance measurements declined over time (P < .001).CONCLUSION: Postoperative LFP activity can be recorded years after DBS implantation and demonstrates a similar profile in response to movement as during acute recordings, although amplitude may decrease. These results support the feasibility of constructing a closed-loop, patient-responsive DBS device based on LFP activity.