RULES FOR THE PRODUCTION OF SENSORY CELLS
RULES FOR THE PRODUCTION OF SENSORY CELLS
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DOI：
10.4171/rmi/104
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发表时间：
1991-01-01
期刊：
影响因子：
--
通讯作者：
LEWIS, J
中科院分区：
文献类型：
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作者：
LEWIS, J
在发育和再生过程中，细胞分裂，移动，改变其内部状态，对环境信号做出反应，并根据其基因组指定的规则死亡。细胞行为的这些规则是解释感觉组织如何产生或修复的基础。本文试图总结和比较四种不同感觉组织的发育规律：哺乳动物视网膜、鸟类听觉上皮、果蝇的机械感觉刚毛区和果蝇视网膜。在细胞谱系、发育决定的时间、分化状态的选择推迟到最后的细胞分裂周期、短程侧抑制的作用以及Notch和achaete/scute等基因的参与方面存在相似之处。这些相似性可能反映了起源于多细胞动物进化早期的感觉发育的一些基本机制的保守性。如果是这样的话，在果蝇中的研究，其分子遗传学的优势，可能会提供重要的线索，在脊椎动物的感觉发育和再生的机制。
During development and regeneration, cells divide, move, change their internal state, respond to environmental signals and die according to rules specified by their genome. These rules of cell behaviour are fundamental to any explanation of how sensory tissues are generated or repaired. An attempt is made to summarize and compare the rules underlying the development of four different sensory tissues: mammalian retina, avian auditory epithelium, mechanosensory bristle fields in Drosophila and, very briefly, Drosophila retina. There are parallels in cell lineage, in the timing of developmental decisions, in the postponement of the choice of differentiated state until the final cell division cycle, in the role of short-range lateral inhibition, and in the involvement of genes such as Notch and achaete/scute. These similarities may reflect the conservation of some basic mechanisms of sensory development that originated early in the evolution of multicellular animals. If so, studies in Drosophila, with its advantages for molecular genetics, may give important clues to the mechanisms of sensory development and regeneration in vertebrates.