Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients
Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients
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DOI：
10.1039/c5cc01868d
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Smith, David K.
中科院分区：
文献类型：
--
作者：
Howe, Edward J.;Okesola, Babatunde O.;Smith, David K.
基于1，3：2，4-二（4-酰肼）亚苄基山梨糖醇（DBS-CONHNH 2）的简单超分子水凝胶能够通过与自组装凝胶纳米纤维的定向相互作用来提取酸官能化抗炎药物。双组分水凝胶-药物杂化材料可以通过混合容易地形成，并表现出pH控制的药物释放。
A simple supramolecular hydrogel based on 1,3:2,4-di(4-acylhydrazide)benzylidene sorbitol (DBS-CONHNH2), is able to-extract acid-functionalised anti-inflammatory drugs via directed interactions with the self-assembled gel nanofibres. Two-component hydrogel-drug hybrid materials can be easily formed by mixing and exhibit pH-controlled drug release.