Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma
Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma
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DOI：
10.1158/1055-9965.epi-09-0334
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发表时间：
2009-09-01
影响因子：
3.8
通讯作者：
Scannapieco, Frank A.
中科院分区：
文献类型：
--
作者：
Tezal, Mine;Sullivan, Maureen A.;Scannapieco, Frank A.
大量证据支持慢性感染/炎症与癌症之间的关联。本研究的目的是评估慢性牙周炎对头颈部鳞状细胞癌（HNSCC）的影响。研究人群包括1999年至2005年罗斯威尔公园癌症研究所牙科和颌面修复科的新患者。例为原发性HNSCC患者。对照组是在同一时间段内观察到但恶性肿瘤阴性的所有患者。在调整年龄、性别、种族/民族、婚姻状况、吸烟状况、饮酒和缺牙后，年龄为4倍的患者HNSCC风险增加（比值比，4.36; 95%置信区间，3.16-6.01）。这种联系的强度在口腔中最大，其次是口咽和喉。这种关联在从不吸烟和饮酒的受试者中持续存在。吸烟与ABL之间存在显著的交互作用（P = 0.03）。牙周炎患者口腔低分化鳞状细胞癌的发生率明显高于无牙周炎患者（32.8%比11.5%; P = 0.038）。这项研究表明，慢性牙周炎是一个独立的危险因素，HNSCC和吸烟修改这种关联。这些结果对HNSCC的预防、诊断和治疗的实用和安全策略具有重要意义。（Cancer Epidemiol Biomarkers Prev 2009; 18（9）：2406-12）
Substantial evidence supports an association between chronic infections/inflammation, and cancer. The aim of this study was to assess the effect of chronic periodontitis on head and neck squamous cell carcinoma (HNSCC). The study population consisted of new patients at the Department of Dentistry and Maxillofacial Prosthetics, Roswell Park Cancer Institute between 1999 and 2005. Cases were patients diagnosed with primary HNSCC. Controls were all patients seen during the same time period but negative for malignancy. Patients age 4-fold increased risk of HNSCC (odds ratio, 4.36; 95% confidence interval, 3.16-6.01) after adjustment for age, gender, race/ethnicity, marital status, smoking status, alcohol use, and missing teeth. The strength of the association was greatest in the oral cavity, followed by oropharynx and larynx. The association persisted in subjects who never used tobacco and alcohol. There was a significant interaction between smoking and ABL (P = 0.03). Patients with periodontitis were more likely to have poorly differentiated oral cavity SCC than those without periodontitis (32.8% versus 11.5%; P = 0.038). This study suggests that chronic periodontitis is an independent risk factor for HNSCC and smoking modifies this association. These results have implications for practical and safe strategies for prevention, diagnosis, and treatment of HNSCC. (Cancer Epidemiol Biomarkers Prev 2009; 18(9):2406-12)