Visual Suppression in Intermittent Exotropia during Binocular Alignment
Visual Suppression in Intermittent Exotropia during Binocular Alignment
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DOI：
10.1167/iovs.10-6144
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发表时间：
2011-04-01
影响因子：
4.4
通讯作者：
Read, Jenny C. A.
中科院分区：
文献类型：
--
作者：
Serrano-Pedraza, Ignacio;Manjunath, Vina;Read, Jenny C. A.
目的.目的探讨间歇性外斜视（X（T））患者在双眼定位（正斜视）过程中防止复视的皮层机制。作者研究了12例年龄5 ~ 22岁的X（T）患者。75%的人具有功能性立体视觉，立体视锐度与12名年龄匹配的对照组相似（0.2-3.7分弧）。在一只眼睛中，脸被呈现在中央凹处;在另一只眼睛中，沿水平轴偏移沿着，偏心率高达12。这项任务是指出是否一个或两个面孔被感知。所有X（T）患者在非中心凹面部出现在鼻侧半视网膜时均表现出正常复视，尽管融合范围比年龄匹配的对照组略大。然而，12名患者中有10名在非中心凹面部呈现于颞侧半视网膜时从未发生复视（即，当刺激物模拟外偏时）。患者表现出相当大的变化时，单一的图像被认为。有些患者抑制颞刺激，不管哪只眼睛看到它，而其他人抑制特定的眼睛，即使它看到了中央凹刺激。在两名患者中，模拟的外斜视可能引发了从正常到异常视网膜对应的转变。在X（T）中的反复视机制可以由正斜视期间的纯视网膜信息可靠地触发，但是这些机制的性质在患者之间不同。（Invest Ophthalmol维斯科学。2011;52：2352-2364）DOI：10.1167/iovs.10-6144
PURPOSE. To investigate the cortical mechanisms that prevent diplopia in intermittent exotropia (X(T)) during binocular alignment (orthotropia).METHODS. The authors studied 12 X(T) patients aged 5 to 22 years. Seventy-five percent had functional stereo vision with stereoacuity similar to that of 12 age-matched controls (0.2-3.7 min arc). Identical face images were presented to the two eyes for 400 ms. In one eye, the face was presented at the fovea; in the other, offset along the horizontal axis with up to 12 eccentricity. The task was to indicate whether one or two faces were perceived.RESULTS. All X(T) patients showed normal diplopia when the nonfoveal face was presented to nasal hemiretina, though with a slightly larger fusional range than age-matched controls. However, 10 of 12 patients never experienced diplopia when the nonfoveal face was presented to temporal hemiretina (i.e., when the stimulus simulated exodeviation). Patients showed considerable variability when the single image was perceived. Some patients suppressed the temporal stimulus regardless of which eye viewed it, whereas others suppressed a particular eye even when it viewed the foveal stimulus. In two patients, the simulated exodeviation might have triggered a shift from normal to anomalous retinal correspondence.CONCLUSIONS. Antidiplopic mechanisms in X(T) can be reliably triggered by purely retinal information during orthotropia, but the nature of these mechanisms varies between patients. (Invest Ophthalmol Vis Sci. 2011;52:2352-2364) DOI: 10.1167/iovs.10-6144