Hepato-biliary late effects in survivors of childhood and adolescent cancer: a report from the Children's Oncology Group.
Hepato-biliary late effects in survivors of childhood and adolescent cancer: a report from the Children's Oncology Group.
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DOI：
10.1002/pbc.22265
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发表时间：
2010-05
影响因子：
3.2
通讯作者：
Hudson, Melissa M.
中科院分区：
文献类型：
--
作者：
Castellino, Sharon;Muir, Andrew;Shah, Ami;Shope, Sheila;McMullen, Kevin;Ruble, Kathy;Barber, Ashley;Davidoff, Andrew;Hudson, Melissa M.
Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children’s Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.
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