Young neurons from medial ganglionic eminence disperse in adult and embryonic brain
Young neurons from medial ganglionic eminence disperse in adult and embryonic brain
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DOI：
10.1038/8131
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发表时间：
1999-05-01
影响因子：
25
通讯作者：
Alvarez-Buylla, A
中科院分区：
文献类型：
--
作者：
Wichterle, H;Garcia-Verdugo, JM;Alvarez-Buylla, A
在这项研究中，我们确定了可以通过成年哺乳动物脑组织分散的神经元前体。移植的神经元前体细胞来自胚胎的内侧神经节隆起（MGE），而不是来自外侧神经节隆起（LGE）或新皮质，分散和分化成神经元在多个成年大脑区域。与此相反，只有LGE细胞能够有效地从成年脑室下区迁移到嗅球。在胚胎脑切片中，MGE细胞向皮质广泛迁移。我们的研究结果表明，在不同的germinal地区的细胞具有独特的迁移潜力，成年哺乳动物的大脑可以支持广泛的分散的特定群体的神经元前体。这些发现可能有助于弥漫性脑损伤的修复。
In this study, we identified neuronal precursors that can disperse through adult mammalian brain tissue. Transplanted neuronal precursors from embryonic medial ganglionic eminence (MGE), but not from lateral ganglionic eminence (LGE) or neocortex, dispersed and differentiated into neurons in multiple adult brain regions. In contrast, only LGE cells were able to migrate efficiently from the adult subventricular zone to the olfactory bulb. In embryonic brain slices, MGE cells migrated extensively toward cortex. Our results demonstrate that cells in different germinal regions have unique migratory potentials, and that adult mammalian brain can support widespread dispersion of specific populations of neuronal precursors. These findings could be useful in repair of diffuse brain damage.