The structural brain correlates of neurological soft signs in healthy individuals
The structural brain correlates of neurological soft signs in healthy individuals
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DOI：
10.1093/cercor/bhj063
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发表时间：
2006-08-01
期刊：
影响因子：
3.7
通讯作者：
Murray, Robin M.
中科院分区：
文献类型：
--
作者：
Dazzan, Paola;Morgan, Kevin D.;Murray, Robin M.
神经软征(NSS)包括运动协调性差、感觉知觉困难和复杂运动任务排序困难，是否由特定或弥漫性脑结构异常引起，目前尚不清楚。研究健康人NSS的神经解剖学基础可能有助于确定哪些大脑区域与这些症状具体相关，同时排除精神和神经疾病的潜在混杂影响。本研究以43名健康受试者为研究对象，采用神经功能评定量表进行神经功能评定，采用高分辨率磁共振成像和体素图像分析方法研究脑结构与神经功能障碍的关系。较高的NSS发生率与额叶下回、中上回和前扣带回的减少有关。值得注意的是，在之前对精神病患者的研究中，我们发现NSS过量与相似皮质区域的减少有关。因此，我们认为，这些皮质脑结构的变化代表了NSS的共同神经解剖学基础，横跨健康人和精神病患者。
It has yet to be established whether neurological soft signs (NSS), which include poor motor coordination, sensory perceptual difficulties and difficulties in sequencing of complex motor tasks, result from specific or diffuse brain structural abnormalities. Studying the neuroanatomical basis of NSS in healthy individuals may help to identify which brain areas are specifically associated with these signs, while excluding the potential confounding effects of psychiatric and neurological disorders. We investigated the relationship between brain structure and NSS in 43 healthy individuals, using the Neurological Evaluation Scale for neurological assessment, and high resolution MRI and voxel-based methods of image analysis to investigate brain structure. Higher rates of NSS were associated with a reduction of inferior frontal gyrus, middle and superior temporal gyrus, and anterior cingulate gyrus. It is of note that in a previous study of patients with psychosis we found that an excess of NSS was associated with a reduction of similar cortical areas. Therefore, we suggest that these cortical brain structural changes represent a common neuroanatomical substrate of NSS, across healthy individuals and patients with psychosis.