The cure of cancer: A European perspective
The cure of cancer: A European perspective
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DOI：
10.1016/j.ejca.2008.11.034
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发表时间：
2009-04-01
影响因子：
8.4
通讯作者：
Janssen-Heijnen, Maryska
中科院分区：
文献类型：
--
作者：
Francisci, Silvia;Capocaccia, Riccardo;Janssen-Heijnen, Maryska
基于癌症登记数据的癌症生存分析并不能提供关于癌症治疗主要目的的直接信息，即患者的治愈。事实上，经典的生存指标并不能区分治愈的患者和将死于疾病的患者，延长生存期是治疗的主要目标。在这项研究中，我们将参数治愈模型应用于49例EUROCARE-4提供的癌症发病率和随访数据。（欧洲癌症登记研究，第四版）癌症登记，目的是提供1988年至1999年诊断的欧洲癌症患者的生存率的额外见解，不同国家的估计治愈患者的比例从肺癌的4-13%不等，胃癌从9%到30%不等，结肠癌和直肠癌从25%到49%不等，乳腺癌从55%到73%不等。对于所有癌症的合并，男性估计为21%至47%，女性为38%至59%，并受到癌症部位病例分布的影响。所有癌症合并的治愈率高且致死性病例生存时间长的国家的特征是病例组合普遍有利。对于欧洲病例库，治愈的比例和致死性病例的生存时间均与年龄相关，并且从早期到最后诊断期增加。据估计，欧洲人治愈肺癌、胃癌、结肠癌和直肠癌的比例随着时间的推移而增加，这是值得注意的，表明在癌症控制方面取得了真正的进展。所有癌症的治愈比例是癌症控制的一个有用的一般指标，因为它反映了诊断和治疗方面的进展，以及在预防快速致命癌症方面的成功。(C)2008爱思唯尔有限公司保留所有权利。
Cancer survival analyses based on cancer registry data do not provide direct information on the main aim of cancer treatment, the cure of the patient. In fact, classic survival indicators do not distinguish between patients who are cured, and patients who will die of their disease and in whom prolongation of survival is the main objective of treatment.In this study, we applied parametric cure models to the cancer incidence and follow-up data provided by 49 EUROCARE-4 (European Cancer Registry-based study, fourth edition) cancer registries, with the aims of providing additional insights into the survival of European cancer patients diagnosed from 1988 to 1999, and of investigating between-population differences.Between-country estimates the proportion of cured patients varied from about 4-13% for lung cancer, from 9% to 30% for stomach cancer, from 25% to 49% for colon and rectum cancer, and from 55% to 73% for breast cancer. For all cancers combined, estimates varied between 21% and 47% in men, and 38% and 59% in women and were influenced by the distribution of cases by cancer site. Countries with high proportions of cured and long fatal case survival times for all cancers combined were characterised by generally favourable case mix. For the European pool of cases both the proportion of cured and the survival time of fatal cases were associated with age, and increased from the early to the latest diagnosis period. The increases over time in the proportions of Europeans estimated cured of lung, stomach and colon and rectum cancers are noteworthy and suggest genuine progress in cancer control. The proportion of cured of all cancers combined is a useful general indicator of cancer control as it reflects progress in diagnosis and treatment, as well as success in the prevention of rapidly fatal cancers. (C) 2008 Elsevier Ltd. All rights reserved.