SYNAPTIC LOCALIZATION OF ADRENERGIC DISINHIBITION IN THE RAT HIPPOCAMPUS
SYNAPTIC LOCALIZATION OF ADRENERGIC DISINHIBITION IN THE RAT HIPPOCAMPUS
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DOI：
10.1016/0896-6273(91)90229-s
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发表时间：
1991-06-01
期刊：
影响因子：
16.2
通讯作者：
MADISON, DV
中科院分区：
文献类型：
--
作者：
DOZE, VA;COHEN, GA;MADISON, DV
去甲肾上腺素是一种内源性神经递质，通过对α-肾上腺素能受体的作用减少对海马体中锥体神经元的突触抑制。 这种去抑制的生理机制以前是未知的，除了它发生在一个网站突触前抑制锥体细胞。 在本文中，我们提出的证据表明，肾上腺素能去抑制仅限于在海马CA 1区的诱发抑制性突触后电位的早期阶段。 解除抑制的位点似乎并不存在于神经元间末梢、轴突或细胞体中。 相反，肾上腺素能激动剂似乎通过抑制激活中间神经元的兴奋性突触来减少诱发的突触抑制。
Norepinephrine is an endogenous neurotransmitter that reduces synaptic inhibition onto pyramidal neurons in the hippocampus by an action at an alpha-adrenergic receptor. The physiological mechanism of this disinhibition was previously not known, except that it occurred at a site presynaptic to the inhibited pyramidal cell. In this paper we present evidence that adrenergic disinhibition is restricted to the early phase of the evoked inhibitory postsynaptic potential in area CA1 of the hippocampus. The locus of disinhibition does not appear to reside in the interneuronal terminal, axon, or cell body. Instead, adrenergic agonists appear to reduce evoked synaptic inhibition by depressing excitatory synapses that activate the interneuron.