Diabetes mellitus and cancer risk in a population-based case-control study among men from Montreal, Canada
Diabetes mellitus and cancer risk in a population-based case-control study among men from Montreal, Canada
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DOI：
10.1002/ijc.21600
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发表时间：
2006-04-15
影响因子：
6.4
通讯作者：
Siemiatycki, J
中科院分区：
文献类型：
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作者：
Rousseau, MC;Parent, ME;Siemiatycki, J
糖尿病患者可能有更高的癌症风险，特别是肝癌和胰腺癌。关于其他癌症类型的证据仍然很少。作者在20世纪80年代在加拿大蒙特利尔进行的一项大型多癌病例对照项目中研究了糖尿病和几种癌症之间的潜在联系。该报告基于3，107例男性癌症病例和509例人群对照，使用了通过访谈收集的糖尿病信息和几个协变量。估计了糖尿病与12种癌症类型之间关系的校正比值比（OR）和95%置信区间（CI）。糖尿病患者中胰腺癌和肝癌的风险增加：胰腺癌和肝癌的校正OR分别为2.1（95% CI：1.0，4.3）和3.1（95% CI：1.1，8.8）。胰腺癌风险的增加完全局限于那些最近发生糖尿病的人;这可能是反向因果关系的表现。相反，肝癌风险的增加与糖尿病和癌症诊断之间的间隔无关。未观察到与黑色素瘤、非霍奇金淋巴瘤、食道癌、胃癌、结肠癌、直肠癌、肺癌、前列腺癌、膀胱癌和肾癌的相关性。总之，糖尿病与男性肝癌风险增加有关，但与包括胰腺癌在内的其他癌症类型无关。(c)2005 Wiley-Liss，Inc.
Diabetics may have a higher risk of cancer, notably liver and pancreatic cancers. Evidence about other cancer types remains sparse. The authors examined potential associations between diabetes and several types of cancer in a large multicancer case-control project carried out in Montreal, Canada, in the 1980s. This report, based on 3,107 male cancer cases and 509 population controls, uses information on diabetes and several covariates collected by interview. Adjusted odds ratios (ORs) and 95% confidence intervals (CI) were estimated for the associations between diabetes and each of 12 cancer types. Risks of pancreatic and liver cancers were increased among diabetics: adjusted ORs were 2.1 (95% CI: 1.0, 4.3) for pancreatic and 3.1 (95% Cl: 1.1, 8.8) for liver cancer. The increased risk of pancreatic cancer was completely restricted to those with recent onset of diabetes; this was likely a manifestation of reverse causality. Conversely, the increased risk of liver cancer was independent of the interval between diabetes and cancer diagnoses. No associations were observed with melanoma, non-Hodgkin's lymphoma, cancers of the esophagus, stomach, colon, rectum, lung, prostate, bladder and kidney. In conclusion, diabetes was associated with an increased risk of liver cancer among men, but with no other cancer type including pancreatic cancer. (c) 2005 Wiley-Liss, Inc.