Paraneoplastic "stiff person syndrome" with metastatic adenocarcinoma and anti-Ri antibodies
Paraneoplastic "stiff person syndrome" with metastatic adenocarcinoma and anti-Ri antibodies
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DOI：
10.1212/01.wnl.0000123694.64121.d5
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发表时间：
2004-04-27
期刊：
影响因子：
9.9
通讯作者：
Schapira, AHV
中科院分区：
文献类型：
--
作者：
McCabe, DJH;Turner, NC;Schapira, AHV
1例43岁女性，临床和电生理特征为僵人综合征，无腹部或腰椎旁肌肉受累。检查发现抗Ri抗体阳性的转移性肺腺癌。通过安定、巴氯芬、替扎尼定和姑息化疗，她的临床情况有所改善。当临床表现不典型时，应考虑对SPS患者进行潜在恶性肿瘤和抗Ri抗体的筛查。
A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with diazepam, baclofen, tizanidine, and palliative chemotherapy. Screening for an underlying malignancy and anti-Ri antibodies should be considered in patients with SPS when clinical presentation is atypical.