Tenascins and the Importance of Adhesion Modulation
Tenascins and the Importance of Adhesion Modulation
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DOI：
10.1101/cshperspect.a004960
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发表时间：
2011-05-01
影响因子：
7.2
通讯作者：
Tucker, Richard P.
中科院分区：
文献类型：
--
作者：
Chiquet-Ehrismann, Ruth;Tucker, Richard P.
腱生蛋白是在早期脊索动物中进化的细胞外基质蛋白家族。有四个家族成员：腱生蛋白-X、腱生蛋白-R、腱生蛋白-W和腱生蛋白-C。腱生蛋白-X与I型胶原蛋白相关，并且其缺失可导致埃勒斯-当洛斯综合征。相比之下，腱生蛋白-R集中在神经元周围的网络中。生腱蛋白-C和生腱蛋白-W的表达受发育调节，并且两者都在疾病期间表达（例如，两者都与癌间质和肿瘤血管有关）。此外，腱生蛋白-C高度由感染和炎症诱导。因此，腱生蛋白-C敲除小鼠具有降低的炎症反应。所有腱生蛋白都有可能直接或通过与纤连蛋白的相互作用改变细胞粘附，并且细胞-腱生蛋白相互作用通常会导致细胞运动性增加。在腱生蛋白-C的情况下，在几种类型的肿瘤中，表达升高与转移增加之间存在相关性。
Tenascins are a family of extracellular matrix proteins that evolved in early chordates. There are four family members: tenascin-X, tenascin-R, tenascin-W, and tenascin-C. Tenascin-X associates with type I collagen, and its absence can cause Ehlers-Danlos Syndrome. In contrast, tenascin-R is concentrated in perineuronal nets. The expression of tenascin-C and tenascin-W is developmentally regulated, and both are expressed during disease (e.g., both are associated with cancer stroma and tumor blood vessels). In addition, tenascin-C is highly induced by infections and inflammation. Accordingly, the tenascin-C knockout mouse has a reduced inflammatory response. All tenascins have the potential to modify cell adhesion either directly or through interaction with fibronectin, and cell-tenascin interactions typically lead to increased cell motility. In the case of tenascin-C, there is a correlation between elevated expression and increased metastasis in several types of tumors.