The Effect of Regular Exercise on Quality of Life Among Breast Cancer Survivors
The Effect of Regular Exercise on Quality of Life Among Breast Cancer Survivors
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DOI：
10.1093/aje/kwp209
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发表时间：
2009-10-01
影响因子：
5
通讯作者：
Shu, Xiao Ou
中科院分区：
文献类型：
--
作者：
Chen, Xiaoli;Zheng, Ying;Shu, Xiao Ou
作者在一项以人群为基础的队列研究中评估了癌症诊断后前 36 个月内定期运动对生活质量 (QOL) 的影响，研究对象为 1,829 名被诊断患有乳腺癌的中国女性。这些女性在 2002 年至 2004 年间被识别出来，并在癌症诊断后约 6 个月被邀请参加这项研究。诊断后大约 6、18 和 36 个月评估运动情况，并得出每周的代谢当量任务 (MET) 评分（以小时为单位）。针对诊断后 36 个月内的定期运动创建累积加权运动 MET 评分。诊断后 6 个月和 36 个月评估 QOL。采用多元线性回归和混合模型来评估定期运动和生活质量之间的关联，并调整临床预后因素和其他潜在的混杂因素。诊断后前 6 个月或 36 个月内测量的运动 MET 评分以及诊断后 36 个月内的加权运动 MET 评分均与诊断后 36 个月评估的总 QOL 评分以及身体、心理和社会幸福感评分呈正相关（所有趋势 P < 0.05）。与不定期锻炼者相比，运动 MET 得分较高（>= 8.3 MET 小时/周）的女性更有可能在总 QOL 和特定 QOL 领域获得较高得分（所有 P < 0.05）。癌症诊断后，随着时间的推移，运动与生活质量的关联保持稳定。这项研究表明乳腺癌诊断后定期锻炼可以改善生活质量。
The authors evaluated the effect of regular exercise during the first 36 months after cancer diagnosis on quality of life (QOL) in a population-based cohort study of 1,829 Chinese women diagnosed with breast cancer. The women were identified between 2002 and 2004 and were invited to participate in the study about 6 months after cancer diagnosis. Exercise was assessed approximately 6, 18, and 36 months after diagnosis, and a metabolic equivalent task (MET) score in hours per week was derived. A cumulative, weighted exercise-MET score was created for regular exercise during the 36-month postdiagnosis period. QOL was evaluated at 6 and 36 months postdiagnosis. Multiple linear regression and mixed models were conducted to evaluate the association between regular exercise and QOL, with adjustment for clinical prognostic factors and other potential confounders. Both exercise-MET scores measured during the first 6 or 36 months postdiagnosis and the weighted exercise-MET score over the 36-month postdiagnosis period were positively associated with total QOL score and physical, psychological, and social well-being scores assessed at 36 months postdiagnosis (all P for trend < 0.05). Compared with nonregular exercisers, women with higher exercise-MET scores (>= 8.3 MET-hours/week) were more likely to have higher scores for total QOL and specific QOL domains (all P < 0.05). The exercise-QOL association remained stable over time after cancer diagnosis. This study suggests that regular exercise after breast cancer diagnosis improves QOL.