GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools
GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools
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DOI：
10.1016/s0896-6273(02)00864-4
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发表时间：
2002-08-29
期刊：
影响因子：
16.2
通讯作者：
deLapeyrière, O
中科院分区：
文献类型：
--
作者：
Haase, G;Dessaud, E;deLapeyrière, O
特定神经元群体对靶标的神经支配涉及中枢和外周因素之间尚未完全了解的相互作用。我们发现，胶质细胞源性神经营养因子（GDNF）最初因其作为一种存活因子的作用而被鉴定，它在发育中的前肢神经丛早期存在，后来在两块肌肉中存在：最大皮肌和背阔肌。在缺乏GDNF信号传导的情况下，通常支配这些肌肉的运动神经元在脊髓内位置错误，并且其轴突对肌肉的侵入显著减少。ETS转录因子PEA3通常由这些运动神经元表达，在GDNF信号传导突变体中，大多数运动神经元中无法诱导产生该因子。因此，GDNF作为一种外周信号，在特定运动神经元池中诱导PEA3表达，从而调节细胞体位置和肌肉神经支配。
Target innervation by specific neuronal populations involves still incompletely understood interactions between central and peripheral factors. We show that glial cell line-derived neurotrophic factor (GDNF), initially characterized for its role as a survival factor, is present early in the plexus of the developing forelimb and later in two muscles: the cutaneus maximus and latissimus dorsi. In the absence of GDNF signaling, motor neurons that normally innervate these muscles are mispositioned within the spinal cord and muscle invasion by their axons is dramatically reduced. The ETS transcription factor PEA3 is normally expressed by these motor neurons and fails to be induced in most of them in GDNF signaling mutants. Thus, GDNF acts as a peripheral signal to induce PEA3 expression in specific motor neuron pools thereby regulating both cell body position and muscle innervation.