Effects of heroin on rat prosocial behavior.
Effects of heroin on rat prosocial behavior.
复制标题
海洛因对大鼠亲社会行为的影响。
DOI：
10.1111/adb.12633
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发表时间：
2019
影响因子：
3.4
通讯作者：
Olive,MFoster
中科院分区：
文献类型：
--
作者：
Tomek,SevenE;Stegmann,GabrielaM;Olive,MFoster
阿片类药物使用障碍的部分特征是社会功能受损。先前的研究表明，经常被用作成瘾相关行为动物模型的实验室老鼠具有亲社会行为的能力。例如，在正常情况下，当一只“自由”老鼠被放置在被塑料限制器困住的老鼠附近时，这只老鼠会释放或“营救”另一只老鼠。本研究旨在确定海洛因对大鼠亲社会行为的影响。在两周的时间里，大鼠有机会将其笼中同伴从禁闭中解救出来，并记录了释放禁闭大鼠的发生情况和潜伏期。建立基线救援行为后，随机选择大鼠自行注射海洛因（0.06 mg/kg/静脉输注）或蔗糖丸（口服）14 天。接下来，连续 3 天每天一次对大鼠的救援行为进行重新测试，在此期间，它们可以选择是释放被困的笼友还是继续自我施用各自的强化物。我们的结果表明，自我施用蔗糖的老鼠继续拯救他们的笼中伙伴，而海洛因老鼠选择自我管理海洛因而不拯救他们的笼中伙伴。这些发现表明，有海洛因自我给药史的大鼠表现出亲社会行为缺陷，这与阿片类药物使用障碍的特定诊断标准一致。在参与亲社会行为和继续吸毒之间提供选择的行为范式可能有助于建模和研究阿片类药物成瘾的社会功能缺陷的神经基础。
Opioid use disorders are characterized in part by impairments in social functioning. Previous research indicates that laboratory rats, which are frequently used as animal models of addiction‐related behaviors, are capable of prosocial behavior. For example, under normal conditions, when a ‘free’ rat is placed in the vicinity of rat trapped in a plastic restrainer, the rat will release or ‘rescue’ the other rat from confinement. The present study was conducted to determine the effects of heroin on prosocial behavior in rats. For 2 weeks, rats were given the opportunity to rescue their cagemate from confinement, and the occurrence of and latency to free the confined rat was recorded. After baseline rescuing behavior was established, rats were randomly selected to self‐administer heroin (0.06 mg/kg/infusion i.v.) or sucrose pellets (orally) for 14 days. Next, rats were retested for rescuing behavior once daily for 3 days, during which they were provided with a choice between freeing the trapped cagemate and continuing to self‐administer their respective reinforcer. Our results indicate that rats self‐administering sucrose continued to rescue their cagemate, whereas heroin rats chose to self‐administer heroin and not rescue their cagemate. These findings suggest that rats with a history of heroin self‐administration show deficits in prosocial behavior, consistent with specific diagnostic criteria for opioid use disorder. Behavioral paradigms providing a choice between engaging in prosocial behavior and continuing drug use may be useful in modeling and investigating the neural basis of social functioning deficits in opioid addiction.