Smoking and mortality among women with type 2 diabetes - The Nurses' Health Study cohort
Smoking and mortality among women with type 2 diabetes - The Nurses' Health Study cohort
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DOI：
10.2337/diacare.24.12.2043
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发表时间：
2001-12-01
期刊：
影响因子：
16.2
通讯作者：
Hu, FB
中科院分区：
文献类型：
--
作者：
Al-Delaimy, WK;Willett, WC;Hu, FB
目的：在护士健康研究队列中评估吸烟与2型糖尿病女性死亡率之间的关系。研究设计与方法-护士健康研究，一项前瞻性的美国注册护士队列，包括1976年至1996年在基线或随访期间诊断为2型糖尿病的7401名女性，这些糖尿病女性的总死亡率和特定原因死亡率是感兴趣的结果。结果-我们记录了20年来(67,420人年)2型糖尿病女性死亡724例。在调整了年龄、高血压和高胆固醇史以及其他心血管危险因素的多因素分析中，与从不吸烟者相比，既往吸烟者的死亡率RRS为1.31(95%CI 1.11-1.55)，现在每天吸烟1-14支的RRS为1.43(0.96-2.14)，现在每天吸烟15-34支的RRS为1.64(1.24-2.17)。当前吸烟者每天吸烟量大于或等于35支(趋势P=0.0002)。与从不吸烟的2型糖尿病患者相比，戒烟10年以上的2型糖尿病患者的死亡率RR为1.11(0.92~1.35)。结论吸烟与2型糖尿病患者死亡率的增加呈剂量-反应关系。此外，戒烟似乎大大降低了这种额外的风险。应该强烈建议糖尿病患者不要吸烟。
OBJECTIVE - To assess the relationship between cigarette smoking and mortality among women with type 2 diabetes in the Nurses' Health Study cohort.RESEARCH DESIGN AND METHODS - The Nurses' Health Study, a prospective cohort of U.S. female registered nurses, included 7,401 women with type 2 diabetes diagnosed at baseline or during follow-up from 1976 to 1996, Total and cause-specific mortality of these diabetic women were the outcomes of interest.RESULTS - We documented 724 deaths during 20 years of follow-up (67,420 person-years) among women with type 2 diabetes. In multivariate analyses, adjusting for age, history of high blood pressure and high cholesterol, and other cardiovascular risk factors, compared with never smokers, the RRs of mortality were 1.31 (95% CI 1.11-1.55) for past smokers, 1.43 (0.96-2.14) for current smokers of 1-14 cigarettes/day, 1.64 (1.24-2.17) for current smokers of 15-34 cigarettes/day, and 2.19 (1.32-3.65) for current Smokers of greater than or equal to 35 cigarettes/day (P for trend = 0.0002). Women with type 2 diabetes who had stopped smoking for greater than or equal to 10 years had a mortality RR of 1.11 (0.92-1.35) compared with diabetic women who were never smokers.CONCLUSIONS - Cigarette smoking is associated in a dose-response manner with an increased mortality among women with type 2 diabetes. Furthermore, quitting smoking appears to decrease this excess risk substantially. Diabetes patients should be strongly advised against smoking.