Quantification of [123I]FP-CIT SPECT brain images:: an accurate technique for measurement of the specific binding ratio
Quantification of [123I]FP-CIT SPECT brain images:: an accurate technique for measurement of the specific binding ratio
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DOI：
10.1007/s00259-006-0155-x
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发表时间：
2006-12-01
影响因子：
9.1
通讯作者：
Fleming, John S.
中科院分区：
文献类型：
--
作者：
Tossici-Bolt, Livia;Hoffmann, Sandra M. A.;Fleming, John S.
目的：描述了一种用于准确定量[I-123] FP-CIT SPECT脑images.Methods中的特异性结合率（SBR）的技术：使用感兴趣区域（ROI）的方法，SBR是从考虑到部分体积效应的总纹状体计数的测量中得出的。操作者干预仅限于放置纹状体ROI，这是一项通过使用几何模板区域来促进的任务。用于分析的图像的定义是自动的，并且包括以最高纹状体信号为中心的大约44 mm厚的“板”内的横轴切片。参考区域是从包封在厚片中的整个脑中的非特异性摄取自动定义的，不包括纹状体区域。进行了一项回顾性研究，包括25个正常和30个异常扫描，根据扫描支持达到的临床诊断进行分类，以评估该技术及其临床实用性的术中和术中变异性。结果：3名操作员重复定量2次，操作员内和操作员间变异系数分别为3%和4%。以4.5为界值区分正常组和异常组的敏感性、特异性和诊断符合率分别为97%、92%和95%.Conclusion：该技术提供了一种重复性好、敏感性高的指标。希望其独立于部分容积效应将提高不同成像设备和分析软件的中心之间定量测量的一致性。
Purpose: A technique is described for accurate quantification of the specific binding ratio (SBR) in [I-123] FP-CIT SPECT brain images.Methods: Using a region of interest (ROI) approach, the SBR is derived from a measure of total striatal counts that takes into account the partial volume effect. Operator intervention is limited to the placement of the striatal ROIs, a task facilitated by the use of geometrical template regions. The definition of the image for the analysis is automated and includes transaxial slices within a "slab" approximately 44 mm thick centred on the highest striatal signal. The reference region is automatically defined from the non-specific uptake in the whole brain enclosed in the slab, with exclusion of the striatal region. A retrospective study consisting of 25 normal and 30 abnormal scans classified by the clinical diagnosis reached with the scan support - was carried out to assess intra-and interoperator variability of the technique and its clinical usefulness. Three operators repeated the quantification twice and the variability was measured by the coefficient of variation (COV).Results: The COVs for intra-and inter-operator variability were 3% and 4% respectively. A cutoff similar to 4.5 was identified that separated normal and abnormal groups with a sensitivity, specificity and diagnostic concordance of 97%, 92% and 95% respectively.Conclusion: The proposed technique provides a reproducible and sensitive index. It is hoped that its independence from the partial volume effect will improve consistency in quantitative measurements between centres with different imaging devices and analysis software.