Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets.
Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets.
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DOI：
10.1155/2014/674987
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发表时间：
2014
影响因子：
2.8
通讯作者：
Kumar A
中科院分区：
文献类型：
--
作者：
Sandireddy R;Yerra VG;Areti A;Komirishetty P;Kumar A
在糖尿病中，影响周围神经的慢性高血糖及其相关并发症是最常见的微血管并发症之一，总患病率为50%-60%。在糖尿病的血管并发症中，糖尿病神经病变是影响患者生活质量的最痛苦、最致残、最致命的并发症。各种病因学理论层出不穷，其中氧化应激介导的神经元及周围神经胶质细胞损伤作为神经病发病的重要机制之一已引起人们的关注。线粒体诱导的ROS和其他氧化剂负责改变氧化剂和体内天然抗氧化防御之间的平衡。氧化-亚硝化应激不仅激活主要途径，即多元醇途径通量、晚期糖基化终末产物的形成、蛋白激酶C的激活和氨基己糖途径的过度活性，而且还启动和放大神经炎症。氧化应激与炎症之间的相互作用是由于激活了NF-κB和AP-1，抑制了NRF2，过氧化亚硝酸盐介导了内皮功能障碍，改变了NO水平，并导致巨噬细胞迁移。所有这些都最终导致促炎细胞因子的产生，这些细胞因子负责神经组织损伤和衰弱的神经疾病。本文就氧化应激与神经炎症在糖尿病神经病变发生发展中的关系作一综述。
In Diabetes, the chronic hyperglycemia and associated complications affecting peripheral nerves are one of the most commonly occurring microvascular complications with an overall prevalence of 50–60%. Among the vascular complications of diabetes, diabetic neuropathy is the most painful and disabling, fatal complication affecting the quality of life in patients. Several theories of etiologies surfaced down the lane, amongst which the oxidative stress mediated damage in neurons and surrounding glial cell has gained attention as one of the vital mechanisms in the pathogenesis of neuropathy. Mitochondria induced ROS and other oxidants are responsible for altering the balance between oxidants and innate antioxidant defence of the body. Oxidative-nitrosative stress not only activates the major pathways namely, polyol pathway flux, advanced glycation end products formation, activation of protein kinase C, and overactivity of the hexosamine pathway, but also initiates and amplifies neuroinflammation. The cross talk between oxidative stress and inflammation is due to the activation of NF-κB and AP-1 and inhibition of Nrf2, peroxynitrite mediate endothelial dysfunction, altered NO levels, and macrophage migration. These all culminate in the production of proinflammatory cytokines which are responsible for nerve tissue damage and debilitating neuropathies. This review focuses on the relationship between oxidative stress and neuroinflammation in the development and progression of diabetic neuropathy.
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DOI：
10.1097/01.asn.0000077408.15865.06
发表时间：
2003-08-01
影响因子：
13.6
作者：
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通讯作者：
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影响因子：
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