Pulsatile urea excretion in Gulf toadfish: the role of circulating serotonin and additional 5-HT receptor subtypes
Pulsatile urea excretion in Gulf toadfish: the role of circulating serotonin and additional 5-HT receptor subtypes
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海湾蟾鱼的脉动尿素排泄：循环血清素和其他 5-HT 受体亚型的作用
DOI：
10.1007/s00360-019-01223-x
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
McDonald, M. Danielle
中科院分区：
文献类型：
--
作者：
Cartolano, Maria C.;Gancel, Haley N.;Lonthair, Joshua;Wood, Chris M.;McDonald, M. Danielle
神经化学物质5-羟色胺（5-HT）通过5-HT 2A受体参与刺激海湾蟾鱼（Opsanus beta）的脉动尿素排泄;然而，尚不清楚（1）5-HT信号是否来源于循环或（2）是否涉及其他5-HT受体亚型。第一个目的是测试5-HT是否可以作为一种激素在控制脉冲尿素排泄通过测量潜在的波动，在循环5-HT对应于尿素脉冲，这将表明循环5-HT可能参与尿素脉冲激活。我们发现，血浆5-HT显着下降38%，1小时后，脉冲检测时鳃尿素排泄显着升高，然后返回到基线。这表明5-HT可能通过清除或排泄从循环中清除，并可能参与终止脉冲尿素排泄。似乎没有从外周组织脉冲释放5-HT来触发尿素脉冲。第二个目的是确定额外的5-HT受体亚型，如额外的5-HT 2受体（5-HT 2C受体）或与cAMP连接的5-HT受体（5-HT 4/6/7受体），是否在刺激尿素排泄中发挥作用。静脉注射5-HT 2C、5-HT 4、5-HT 6和5-HT 7受体激动剂未导致尿素脉冲，表明这些受体以及cAMP不参与刺激尿素排泄。循环5-HT和5-HT 2A受体参与了尿素脉冲排泄的调节，这可能为了解其适应性意义提供了线索。
The neurochemical serotonin (5-HT) is involved in stimulating pulsatile urea excretion in Gulf toadfish (Opsanus beta) through the 5-HT2Areceptor; however, it is not known if (1) the 5-HT signal originates from circulation or if (2) additional 5-HT receptor subtypes are involved. The first objective was to test whether 5-HT may be acting as a hormone in the control of pulsatile urea excretion by measuring potential fluctuations in circulating 5-HT corresponding with a urea pulse, which would suggest circulating 5-HT may be involved with urea pulse activation. We found that plasma 5-HT significantly decreased by 38% 1 h after pulse detection when branchial urea excretion was significantly elevated and then returned to baseline. This suggests that 5-HT is removed from the circulation, possibly through clearance or excretion, and may be involved in the termination of pulsatile urea excretion. There appeared to be no pulsatile release of 5-HT from peripheral tissues to trigger a urea pulse. The second objective was to determine if additional 5-HT receptor subtypes, such as an additional 5-HT2receptor (5-HT2Creceptor) or the 5-HT receptors that are linked to cAMP (5-HT4/6/7receptors), played a role in the stimulation of urea excretion. Intravenous injection of 5-HT2C, 5-HT4, 5-HT6, and 5-HT7receptor agonists did not result in a urea pulse, suggesting that these receptors, and thus cAMP, are not involved in stimulating urea excretion. The involvement of circulating 5-HT and the 5-HT2Areceptor in the regulation of pulsatile urea excretion may provide insight into its adaptive significance.
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脉冲尿素排泄是否可以作为海湾蟾蜍 Opsanus beta 的社交信号？*
影响因子：
1.6
作者：
K. Sloman;M. McDonald;J. Barimo;O. Lepage;S. Winberg;C. Wood;P. Walsh
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DOI：
10.1016/j.cbpa.2012.07.013
发表时间：
2012-11-01
影响因子：
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影响因子：
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激素通过鱼鳃代谢。
DOI：
10.1016/s1095-6433(97)00406-6
发表时间：
1998
期刊：
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
影响因子：
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作者：
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通讯作者：
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海湾蟾鱼的脉动尿素排泄：机制和控制。
DOI：
--
发表时间：
2003
期刊：
Comparative Biochemistry and Physiology Part B Comparative Biochemistry
影响因子：
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作者：
C. Wood;M. McDonald;L. Sundin;P. Laurent;P. Walsh
通讯作者：
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