Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States.
Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States.
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DOI：
10.1111/nyas.12098
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发表时间：
2013-04
影响因子：
5.2
通讯作者：
Chan JC
中科院分区：
文献类型：
--
作者：
Ma RC;Chan JC
糖尿病在亚洲很流行。2型糖尿病在东亚患者中的平均体重指数（BMI）低于欧洲血统的患者。在任何给定的BMI下，东亚人都有更大量的身体脂肪和内脏肥胖的倾向。在亚洲患者中，糖尿病的发病年龄较小，其特征是在胰岛素抵抗背景下出现早期β细胞功能障碍，许多患者需要早期胰岛素治疗。越来越多的成年人和儿童2型糖尿病构成了特别的威胁，这些患者患糖尿病并发症的风险增加。东亚2型糖尿病患者发生肾脏并发症的风险高于欧洲人，就心血管并发症而言，易患中风。除了心血管-肾脏疾病之外，癌症正在成为另一个主要的死亡原因。虽然需要更多的研究来解释这些种族间的差异，但需要采取紧急和协调一致的行动来提高认识，促进早期诊断，并鼓励预防战略，以应对这些日益增长的疾病负担。
There is an epidemic of diabetes in Asia. Type 2 diabetes develops in East Asian patients at a lower mean body mass index (BMI) compared with those of European descent. At any given BMI, East Asians have a greater amount of body fat and a tendency to visceral adiposity. In Asian patients, diabetes develops at a younger age and is characterized by early β cell dysfunction in the setting of insulin resistance, with many requiring early insulin treatment. The increasing proportion of young-onset and childhood type 2 diabetes is posing a particular threat, with these patients being at increased risk of developing diabetic complications. East Asian patients with type 2 diabetes have a higher risk of developing renal complications than Europeans and, with regard to cardiovascular complications, a predisposition for developing strokes. In addition to cardiovascular–renal disease, cancer is emerging as the other main cause of mortality. While more research is needed to explain these interethnic differences, urgent and concerted actions are needed to raise awareness, facilitate early diagnosis, and encourage preventive strategies to combat these growing disease burdens.
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