Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching
Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching
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帕金森病患者患普通感冒的风险较低吗？
DOI：
10.1016/j.parkreldis.2022.11.019
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Maruyama Hirofumi
中科院分区：
文献类型：
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作者：
Neshige Shuichiro;Aoki Shiro;Nezu Tomohisa;Nakamori Masahiro;Yamazaki Yu;Ohshita Tomohiko;Maruyama Hirofumi
越来越多的证据表明炎症反应在帕金森病(PD)的发生发展中起着至关重要的作用，这为生理性α-突触核蛋白在PD非进展期的炎症反应中可能起到重要作用提供了一个假说。因此，我们比较了帕金森病患者与其他常见脑病患者患普通感冒的风险。方法我们从2010年至2021年可获得的保险索赔数据中提取帕金森病(非进展期；非痴呆症)和对照组(AD：阿尔茨海默病、偏头痛、癫痫和缺血性中风)患者的数据。结果帕金森病患者(n=726)和对照组(AD组=1,019例，偏头痛组=1,319例，癫痫组=1,3414例，缺血性卒中组=6,6943例)中有1 186例(9.5%)被诊断为感冒，这与女性(优势比：OR1.59；95%可信区间1.41-1.79；P<；0.0001)独立相关。诊断为帕金森病(OR0.30；95%CI0.20-0.45；P<；0.0001)和新冠肺炎大流行时期(OR0.58%；95%CI0.47-0.72；P<；0.0001)。倾向评分匹配后，帕金森病患者感冒发生率(3.4%)显著低于对照组(9.8%；P<；0.0001)、偏头痛(13.3%；P<；0.0001)、癫痫(11.0%；P<；0.0001)、缺血性中风(8.8%；P<；0.0001)。然而，需要检查几个混杂的因素。此外，α-突触核蛋白可能通过激活非晚期PD患者因慢性炎症而引起的免疫系统来提供对病毒感染的保护性抵抗力。
IntroductionAccumulating evidence indicating that inflammatory responses play crucial roles in Parkinson's disease (PD) development provided a hypothesis that physiological alpha-synuclein may contribute to inflammatory responses against infections during non-advanced stages of PD. Thus, we examined the risk of catching a common cold in patients with PD as compared to other common brain diseases.MethodsWe extracted PD (non-advanced; without dementia) and control (AD: Alzheimer's disease, migraine, epilepsy, and ischemic stroke) patient data from insurance claim data available between 2010 and 2021. After confirming the clinical PD diagnosis, we investigated factors associated with cold diagnoses and used propensity score matching to identify differences in the incidence of colds between PD and control patients.ResultsDiagnosis of colds in PD patients (n = 726) and controls (AD = 377, migraine = 1019, epilepsy = 3414, ischemic stroke = 6943) was found in 1186 (9.5%) patients, which was independently associated with being female (odds ratio: OR 1.59; 95%CI 1.41–1.79;P< 0.0001), follow-up by neurologists (OR 1.30; 95%CI 1.15–1.48;P< 0.0001), diagnosis of PD (OR 0.30; 95%CI 0.20–0.45;P< 0.0001) and COVID-19 pandemic period (OR 0.58; 95%CI 0.47–0.72;P< 0.0001). After propensity score matching, the incidence of colds was significantly lower in PD (3.4%) versus in controls; AD (9.8%;P< 0.0001), migraine (13.3%;P< 0.0001), epilepsy (11.0%;P< 0.0001), ischemic stroke (8.8%;P< 0.0001).ConclusionsPatients with PD were less likely to be diagnosed with colds. However, several confounding factors will need to be examined. Moreover, alpha-synuclein may provide protective resistance to viral infections by activating the immune system due to chronic inflammation in non-advanced PD patients.