Aquatic exercise improves the monocyte pro- and anti-inflammatory cytokine production balance in fibromyalgia patients
Aquatic exercise improves the monocyte pro- and anti-inflammatory cytokine production balance in fibromyalgia patients
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DOI：
10.1111/j.1600-0838.2010.01132.x
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发表时间：
2012-02-01
影响因子：
4.1
通讯作者：
Garcia, J. J.
中科院分区：
文献类型：
--
作者：
Ortega, E.;Bote, M. E.;Garcia, J. J.
目前纤维肌痛（FM）病因学的假设包括炎症性疾病。我们评估了一组女性FM患者的游泳池水上运动计划（8个月，每周两次，每次60分钟）对分离的单核细胞产生的炎症细胞因子和血清C反应蛋白（CRP）浓度的影响。FM患者的单核细胞比年龄匹配的健康女性对照组（HW）释放更多的IL-1 β、TNF α、IL-6和IL-10。FM妇女的这种炎症性疾病也表现为高循环CRP浓度。在4个月（中途）的运动计划后发现IL-6增加，伴随TNF α自发释放减少。在程序结束时（8个月），来自FM患者的单核细胞显示促炎/抗炎细胞因子的自发产生减少，IL-1 β和IL-6的自发释放与HW的相似，但TNF α的产生较低，IL-10的产生较高。脂多糖诱导的IL-1 β、TNF α、IL-6和IL-10的产生在运动计划结束时也减少，尽管IL-10仍然高于HW。运动计划的抗炎作用也通过循环CRP浓度的降低得到证实。运动还改善了FM患者的健康相关生活质量。
Current hypotheses of the etiology of fibromyalgia (FM) include inflammatory disorders. We evaluated the effect of a pool-aquatic exercise program (8 months, two weekly 60-min sessions) on the inflammatory cytokine production by isolated monocytes, and on the serum concentration of C-reactive protein (CRP), in a group of female FM patients. Monocytes from FM patients released more IL-1 beta, TNFa, IL-6, and IL-10 than those from an age-matched control group of healthy women (HW). This inflammatory disorder in FM women was also manifested by high circulating concentrations of CRP. Increased IL-6 with a concomitant decreased TNFa spontaneous release was found after 4 months (midway through) of the exercise program. At the end of the program (8 months), monocytes from FM patients showed diminished spontaneous production of pro-/anti-inflammatory cytokines, with a similar spontaneous release of IL-1 beta and IL-6 to that of HW, but a lower production of TNFa and higher of IL-10. Lipopolysaccharide-induced production of IL-1 beta, TNFa, IL-6, and IL-10 also decreased at the end of the exercise program, although IL-10 remained higher than HW. The anti-inflammatory effect of the exercise program was also corroborated by a decrease in the circulating CRP concentration. Exercise also improved the health-related quality of life of FM patients.